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I find all the discussion on Rytary interesting - I began self-dosing Sue, my wife with PD, about a year ago with MY version of Rytary. She had been on 50-200 ER, every 4 hours and was not tolerating it well. I switched her to 25-100 1st thing in the morning, followed in 2 hours with 1 50-200 ER plus 1/2 of a 25-100, followed in 3 hours with another 25-100, and 2 hrs later another 50-200 + 1/2 25-100, and a 25-100 3 hours later. I think the 1/2 25-100 with the ER really made a difference, starting the effectiveness quickly followed by the longer results from the 50-200 ER. I kept saying I should've patented it! Anyway, she seems to be doing much better on this plan than any before, and I've found I can "fudge" a little as necessary with earlier or later doses depending on her reactions. John, caregiver foe Sue, age 74, PD since 2003 (or before!) ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn