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Anyone here have any experience with or knowledge of nicotinamide ribose or nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotidephosphate (NADPH)? Nicotinamide ribose is a B vitamin and is available over the counter. I believe it has been officially approved for use with PD. A friend who does not have PD told me he started taking it for sleep problems and an assorment of difficulties asociated with depression and chronic pain, and that he shows remarkable improvement across the board; he is enthusiastic about it. Our GP took a look at the literature in pubmed and elsewhere (below), and gave it her OK for both PD patient and care-giver (me). As did her neurologist, a PD specialist. Here are the citations. 1- The clinical effect of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotidephosphate (NADPH). http://www.ncbi.nlm.nih.gov/pubmed/2618590 2- "The coenzyme nicotinamide adenine dinucleotide (NADH) improves the disability of parkinsonian patients." http://www.ncbi.nlm.nih.gov/pubmed/2597315 3- Nicotinamidadenindinucleotide (NADH): the new approach in the therapy of Parkinson's disease. http://www.ncbi.nlm.nih.gov/pubmed/2644889 - Une autre en 1990 : "The clinical benefit of NADH as stimulator of endogenous L-dopa biosynthesis in parkinsonian patients." http://www.ncbi.nlm.nih.gov/pubmed/2239495 - Puis en 1993 : "Nicotinamide adenine dinucleotide (NADH) - a new therapeutic approach to Parkinson's disease. Comparison of oral and parenteral application." http://www.ncbi.nlm.nih.gov/pubmed/8101414 - En 1996, Pr Kuhn et collègues : "Treatment of Parkinson's disease with NADH." http://www.ncbi.nlm.nih.gov/pubmed/9013405 MORE RECENT is this intriguing item based on work of Peter Sinclair, MD of Harvard Med School: https://hms.harvard.edu/news/genetics/new-reversible-cause-aging-12-19-13 Nicotinide ribose "Dr Sinclair, see above, patented a precurser for Nad, helping the cells sirtuins functionning like young ones. Ours function at 40%. "It is a b3 vitamin analog. No Rx. Got mine here http://m.hpnsupplements.com/product/niagen " My friend writes: >Nad+ dose: FOR ME, 180 POUNDS, i take 2Å~ 125mg >pill before breakfast since it affwcts your >circadian cycle. I dont know when you wake up >but this is the right time. If i take some in >the afternoon, i dont sleep at night. >For your wife, light weight, maybe starting with >only one. And evaluate after 2 months. There is >no known side effects with doses up to 1000 mg, >the max dose given during trials conducted by dr >Sinclair. Your system will not make use of nad >if the sirtuins receptors are all filled anyway. >I know a man who guinea pigged himself with a >dose of 5000 mg. No side effects but not more >effective than 1000. >I stopped taking it for 3 weeks, being lousy >about reordering and my before life reappeared: >my acouphen, my elbow pain, bad sleep, lower >optimism... it works! I would be interested to hear from list members. Thanks. Walter ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn