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ORGANIZER;CN=Natalie Leung:MAILTO:[log in to unmask]
ATTENDEE;ROLE=REQ-PARTICIPANT;PARTSTAT=NEEDS-ACTION;RSVP=TRUE;CN="SOCAAR-l:
Southern Ontario Centre for Atmospheric Aerosol Research":MAILTO:SOCAAR-L@l
istserv.utoronto.ca
ATTENDEE;ROLE=REQ-PARTICIPANT;PARTSTAT=NEEDS-ACTION;RSVP=TRUE;CN=Hui Peng:M
AILTO:[log in to unmask]
ATTACH:CID:[log in to unmask]
DESCRIPTION;LANGUAGE=en-US:Hi Everyone\,\n\nSOCAAR is pleased to announce o
ur first Seminar for 2017-2018:\nWednesday November 1\, 2017\n3:00PM – 4
:00PM\n200 College Street\, WB 407\n\n\nOxidative Stress: a Merged Toxic P
athway for Environmental Matrices\nProf. Hui Peng\nAssistant Professor\,\n
Department of Chemistry\nUniversity of Toronto\n\nOxidative stress has bee
n suggested to be the primary toxic pathway of air particulate matter (PM)
to cause cardiovascular disease and other adverse effects. In this talk\,
oxidative stress was demonstrated as the primary toxic pathway for both d
isinfection by-products (DBPs) in drinking water\, and oil sands-processed
water (OPSW). To this end\, a hybrid platform was established in our grou
p to identify toxic components and their modes of action (MOA) from these
critical environmental matrices. High-throughput and reproducible in vitro
cell reporter system was used to determine the Nrf2-mediated oxidative st
ress response from environmental mixtures. Then\, Effect-Directed Analysis
(EDA) and chemical probe\, combined with untargeted chemical analysis\, w
ere used accordingly to identify toxic components. Specifically\, more th
an 600 DBPs were identified in the drinking water after disinfection and d
irect reaction with cysteine was elucidated as the primary pathway for DBP
s to cause oxidative stress. Accordingly\, a biotin/cysteine chemical prob
e was synthesized to identify toxic DBPs. For OSPW whose oxidative stress
may primarily be caused by indirect pathways\, EDA combined with untargete
d chemical analysis was used to identify hydroxylated aldehydes as the pri
mary toxic components. Studies regarding PM samples are still ongoing\, an
d preliminary data shown that chemical probe is an efficient approach to i
dentify toxic components (i.e. quinone) in PM samples. Thus\, our hybrid p
latform may provide a versatile and accessible approach in elucidating the
oxidative stress promoting components in a variety of environmental matri
ces.\n\n\nIf you are unable to join us for the seminar in person\, we will
be broadcasting the presentations live during the seminar using GoToMeeti
ng software. Please feel free to join us online using a web-browser or by
calling in and using the webviewing software. If you do decide to join us\
, please remember to mute your microphone. If you have any questions duri
ng the meeting you are welcome to contact me by email\, or by using the Go
ToMeeting chat.\n\nPlease join my meeting from your computer\, tablet or s
martphone.\nhttps://global.gotomeeting.com/join/432885821\n\nYou can also
dial in using your phone.\nCanada: +1 (647) 497-9376\n\nAccess Code: 432-8
85-821\n\nFirst GoToMeeting? Let's do a quick system check: https://link.g
otomeeting.com/system-check\n\n\n\nKind Regards\,\nNatalie Leung\nFinancia
l and Administrative Assistant | Southern Ontario Centre for Atmospheric A
erosol Research\, University of Toronto\nwww.socaar.utoronto.ca\n\nProgram
Coordinator | Collaborative Program in Engineering Education\, University
of Toronto\nwww.uoft.me/EngEd\n200 College Street\, Toronto\, ON\, Canada
\, M5S 3E5\n• 416 978 5932 | • [log in to unmask][log in to unmask]>\n\n\n
SUMMARY;LANGUAGE=en-US:SOCAAR Seminar - Prof. Hui Peng
DTSTART;TZID=Eastern Standard Time:20171101T150000
DTEND;TZID=Eastern Standard Time:20171101T160000
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CLASS:PUBLIC
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DTSTAMP:20171017T184537Z
TRANSP:OPAQUE
STATUS:CONFIRMED
SEQUENCE:0
LOCATION;LANGUAGE=en-US:WB407\, 200 College St
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