I found this interesting! Damn, ONLY $4 Billion! "In 2015, the company's hepatitis C treatment sales peaked at $12.5 billion. treatments will bring in less than $4 billion this year." John, caregiver for Sue 5/13/2016, RIP -----Original Message----- >From: Trauti Boyd <[log in to unmask]> >Sent: Apr 20, 2018 4:10 AM >To: [log in to unmask] >Subject: Re: Nuplazid > >hi, ray! you must have missed goldman sachs' recent analysis of a >'one-shot cure' : > >/Analyst Salveen Richter and colleagues laid it out: "The potential to >deliver 'one shot cures' is one of the most attractive aspects of gene >therapy, genetically engineered cell therapy, and gene editing. However, >such treatments offer a very different outlook with regard to recurring >revenue versus chronic therapies... While this proposition carries >tremendous value for patients and society, it could represent a >challenge for genome medicine developers looking for sustained cash flow." > >For a real-world example, they pointed to Gilead Sciences, which markets >treatments for hepatitis C that have cure rates exceeding 90 percent. In >2015, the company's hepatitis C treatment sales peaked at $12.5 billion. >But as more people were cured and there were fewer infected individuals >to spread the disease, sales began to languish. Goldman Sachs analysts >estimate that the treatments will bring in less than $4 billion this >year. [Gilead]'s rapid rise and fall of its hepatitis C franchise >highlights one of the dynamics of an effective drug that permanently >cures a disease, resulting in a gradual exhaustion of the prevalent pool >of patients," the analysts wrote. The report noted that diseases such as >common cancers -- where the "incident pool remains stable" -- are less >risky for business./ > > >On 4/19/2018 11:02 PM, Rayilyn Brown wrote: >> Hi Trauti, >> >> I guess I have a negative feeling re all these PD meds. I've taken >> Rytary and Rimantadine for over a year now without trouble but no >> real help either. Wonder how the Tasigna trials are going. The >> powers that be have a big nerve preventing its approval for PD when >> so many approved PD meds have such dreadful side effects. Amantadine >> helped for about a month before all hell broke lose. I'm betting on >> the Rytary rather than PD progression because these are such powerful >> drugs. >> >> I not only hate getting worse but I can't fight so much anymore. >> >> -----Original Message----- From: Trauti Boyd >> Sent: Wednesday, April 18, 2018 4:12 AM >> To: [log in to unmask] >> Subject: Re: Nuplazid >> >> hi, ray! i'm not sure if amantedine is responsible for nic's >> hallucinations or a progression of pd. my husband is getting them more >> and more these days and the only pd medicine he takes are 2 rytary >> 61/245 per day. naturally, i have no way of knowing if the >> levodopa/carbidopa might be the cause of this. >> >> and yes - it's a hateful disease with no improvements in sight! :( >> >> >> On 4/18/2018 12:26 AM, Rayilyn Brown wrote: >>> how I hate this disease! do you get ANY good from these meds? >>> >>> -----Original Message----- From: Nic Marais >>> Sent: Monday, April 16, 2018 4:21 PM >>> To: [log in to unmask] >>> Subject: Re: Nuplazid >>> >>> Ray >>> >>> Any spot on the wall grows legs and start moving... :-) >>> >>> Visual hals are worse when I take my glasses off. >>> >>> I think what causes the hals is the brain trying to make sense out of >>> the >>> noise (Of running bathwater, flushing toilet, unfocused spots, dark room >>> with lots of shadows). Somehow Amantedine triggers this reaction. >>> >>> Something completely different; >>> >>> When I sit or stand in one position, I progressesively lean over to the >>> left. It's very suttle and drives my wife bonckers. Reading a book, I >>> catch >>> myself hanging on the table with my left hand, my head at an angle of >>> about 45 degrees to the book. The other night I actually fell out of the >>> chair... I suspect it is my lefthand back muscles. My left is more shaky >>> than my right. >>> >>> Regards >>> >>> Nic >>> >>> On Sat, Apr 14, 2018, 08:00 Rayilyn Brown <[log in to unmask]> wrote: >>> >>>> Nic >>>> >>>> Now I know what those conversations I hear in living room are. And I'm >>>> getting hard of hearing. >>>> >>>> After a month Amantadine really did I number on me, not so nice. >>>> Besides >>>> animals, monsters and dead people a thin saran-like substance was >>>> all over >>>> everything! my neuro said this substance was the most common >>>> Amantadine >>>> hallucination. and it helped me but I had to quit it, couldn't >>>> stand the >>>> hals. Have taken Rimantadine for over a year and except for one day >>>> when >>>> I >>>> thought I was seeing s mall black insects ive ben OK except it doesn't >>>> help >>>> much. nothing does >>>> >>>> -----Original Message----- >>>> From: Nic Marais >>>> Sent: Tuesday, April 10, 2018 5:20 PM >>>> To: [log in to unmask] >>>> Subject: Re: Nuplazid >>>> >>>> I guess I have to get used to all the animals and people in the >>>> house. They >>>> hide behind the bedroom curtains occasionally slipping a hand out and >>>> wave at me. >>>> >>>> They also sit on my bed and turn into big rats running on my bed >>>> cover. >>>> This is only the visual hals. The sound ones are the most difficult to >>>> judge if it's reality or a hal... I don't mind the music when I >>>> flush the >>>> toilet or run the bathWater. It's rather pleasant ;-) It's the >>>> whispers and >>>> conversations and loud bangs that is very disturbing at times' >>>> >>>> Anybody like to share their hals on the list? Should be interesting ;-) >>>> >>>> Nic 66/24 >>>> >>>> >>>> On Apr 10, 2018 8:08 AM, "Rayilyn Brown" <[log in to unmask]> wrote: >>>> >>>> yes, I saw this too >>>> >>>> >>>> -----Original Message----- >>>> From: Maryse Schild >>>> Sent: Monday, April 09, 2018 10:35 AM >>>> To: [log in to unmask] >>>> Subject: Nuplazid >>>> >>>> beware: >>>> >>>> >>>> https://edition.cnn.com/2018/04/09/health/parkinsons-drug-nuplazid-invs/index.html >>>> >>>> >>>> maryse >>>> >>>> ---------------------------------------------------------------------- >>>> To sign-off Parkinsn send a message to: mailto: >>>> [log in to unmask] >>>> In the body of the message put: signoff parkinsn >>>> >>>> ---------------------------------------------------------------------- >>>> To sign-off Parkinsn send a message to: mailto: >>>> [log in to unmask] >>>> In the body of the message put: signoff parkinsn >>>> >>>> ---------------------------------------------------------------------- >>>> To sign-off Parkinsn send a message to: mailto: >>>> [log in to unmask] >>>> In the body of the message put: signoff parkinsn >>>> >>>> ---------------------------------------------------------------------- >>>> To sign-off Parkinsn send a message to: mailto: >>>> [log in to unmask] >>>> In the body of the message put: signoff parkinsn >>>> >>> >>> ---------------------------------------------------------------------- >>> To sign-off Parkinsn send a message to: >>> mailto:[log in to unmask] >>> In the body of the message put: signoff parkinsn >>> ---------------------------------------------------------------------- >>> To sign-off Parkinsn send a message to: >>> mailto:[log in to unmask] >>> In the body of the message put: signoff parkinsn >>> >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn >> > > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn