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hi, ray! you must have missed goldman sachs' recent analysis of a 'one-shot cure' : /Analyst Salveen Richter and colleagues laid it out: "The potential to deliver 'one shot cures' is one of the most attractive aspects of gene therapy, genetically engineered cell therapy, and gene editing. However, such treatments offer a very different outlook with regard to recurring revenue versus chronic therapies... While this proposition carries tremendous value for patients and society, it could represent a challenge for genome medicine developers looking for sustained cash flow." For a real-world example, they pointed to Gilead Sciences, which markets treatments for hepatitis C that have cure rates exceeding 90 percent. In 2015, the company's hepatitis C treatment sales peaked at $12.5 billion. But as more people were cured and there were fewer infected individuals to spread the disease, sales began to languish. Goldman Sachs analysts estimate that the treatments will bring in less than $4 billion this year. [Gilead]'s rapid rise and fall of its hepatitis C franchise highlights one of the dynamics of an effective drug that permanently cures a disease, resulting in a gradual exhaustion of the prevalent pool of patients," the analysts wrote. The report noted that diseases such as common cancers -- where the "incident pool remains stable" -- are less risky for business./ On 4/19/2018 11:02 PM, Rayilyn Brown wrote: > Hi Trauti, > > I guess I have a negative feeling re all these PD meds. I've taken > Rytary and Rimantadine for over a year now without trouble but no > real help either. Wonder how the Tasigna trials are going. The > powers that be have a big nerve preventing its approval for PD when > so many approved PD meds have such dreadful side effects. Amantadine > helped for about a month before all hell broke lose. I'm betting on > the Rytary rather than PD progression because these are such powerful > drugs. > > I not only hate getting worse but I can't fight so much anymore. > > -----Original Message----- From: Trauti Boyd > Sent: Wednesday, April 18, 2018 4:12 AM > To: [log in to unmask] > Subject: Re: Nuplazid > > hi, ray! i'm not sure if amantedine is responsible for nic's > hallucinations or a progression of pd. my husband is getting them more > and more these days and the only pd medicine he takes are 2 rytary > 61/245 per day. naturally, i have no way of knowing if the > levodopa/carbidopa might be the cause of this. > > and yes - it's a hateful disease with no improvements in sight! :( > > > On 4/18/2018 12:26 AM, Rayilyn Brown wrote: >> how I hate this disease! do you get ANY good from these meds? >> >> -----Original Message----- From: Nic Marais >> Sent: Monday, April 16, 2018 4:21 PM >> To: [log in to unmask] >> Subject: Re: Nuplazid >> >> Ray >> >> Any spot on the wall grows legs and start moving... :-) >> >> Visual hals are worse when I take my glasses off. >> >> I think what causes the hals is the brain trying to make sense out of >> the >> noise (Of running bathwater, flushing toilet, unfocused spots, dark room >> with lots of shadows). Somehow Amantedine triggers this reaction. >> >> Something completely different; >> >> When I sit or stand in one position, I progressesively lean over to the >> left. It's very suttle and drives my wife bonckers. Reading a book, I >> catch >> myself hanging on the table with my left hand, my head at an angle of >> about 45 degrees to the book. The other night I actually fell out of the >> chair... I suspect it is my lefthand back muscles. My left is more shaky >> than my right. >> >> Regards >> >> Nic >> >> On Sat, Apr 14, 2018, 08:00 Rayilyn Brown <[log in to unmask]> wrote: >> >>> Nic >>> >>> Now I know what those conversations I hear in living room are. And I'm >>> getting hard of hearing. >>> >>> After a month Amantadine really did I number on me, not so nice. >>> Besides >>> animals, monsters and dead people a thin saran-like substance was >>> all over >>> everything! my neuro said this substance was the most common >>> Amantadine >>> hallucination. and it helped me but I had to quit it, couldn't >>> stand the >>> hals. Have taken Rimantadine for over a year and except for one day >>> when >>> I >>> thought I was seeing s mall black insects ive ben OK except it doesn't >>> help >>> much. nothing does >>> >>> -----Original Message----- >>> From: Nic Marais >>> Sent: Tuesday, April 10, 2018 5:20 PM >>> To: [log in to unmask] >>> Subject: Re: Nuplazid >>> >>> I guess I have to get used to all the animals and people in the >>> house. They >>> hide behind the bedroom curtains occasionally slipping a hand out and >>> wave at me. >>> >>> They also sit on my bed and turn into big rats running on my bed >>> cover. >>> This is only the visual hals. The sound ones are the most difficult to >>> judge if it's reality or a hal... I don't mind the music when I >>> flush the >>> toilet or run the bathWater. It's rather pleasant ;-) It's the >>> whispers and >>> conversations and loud bangs that is very disturbing at times' >>> >>> Anybody like to share their hals on the list? Should be interesting ;-) >>> >>> Nic 66/24 >>> >>> >>> On Apr 10, 2018 8:08 AM, "Rayilyn Brown" <[log in to unmask]> wrote: >>> >>> yes, I saw this too >>> >>> >>> -----Original Message----- >>> From: Maryse Schild >>> Sent: Monday, April 09, 2018 10:35 AM >>> To: [log in to unmask] >>> Subject: Nuplazid >>> >>> beware: >>> >>> >>> https://edition.cnn.com/2018/04/09/health/parkinsons-drug-nuplazid-invs/index.html >>> >>> >>> maryse >>> >>> ---------------------------------------------------------------------- >>> To sign-off Parkinsn send a message to: mailto: >>> [log in to unmask] >>> In the body of the message put: signoff parkinsn >>> >>> ---------------------------------------------------------------------- >>> To sign-off Parkinsn send a message to: mailto: >>> [log in to unmask] >>> In the body of the message put: signoff parkinsn >>> >>> ---------------------------------------------------------------------- >>> To sign-off Parkinsn send a message to: mailto: >>> [log in to unmask] >>> In the body of the message put: signoff parkinsn >>> >>> ---------------------------------------------------------------------- >>> To sign-off Parkinsn send a message to: mailto: >>> [log in to unmask] >>> In the body of the message put: signoff parkinsn >>> >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn >> > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn