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This is exasperating..! It underlines what we've been saying all along; That a cure is not in the interest of the big pharmos... Nic On Sat, Apr 21, 2018, 08:00 Trauti Boyd <[log in to unmask]> wrote: > hi, ray! you must have missed goldman sachs' recent analysis of a > 'one-shot cure' : > > /Analyst Salveen Richter and colleagues laid it out: "The potential to > deliver 'one shot cures' is one of the most attractive aspects of gene > therapy, genetically engineered cell therapy, and gene editing. However, > such treatments offer a very different outlook with regard to recurring > revenue versus chronic therapies... While this proposition carries > tremendous value for patients and society, it could represent a > challenge for genome medicine developers looking for sustained cash flow." > > For a real-world example, they pointed to Gilead Sciences, which markets > treatments for hepatitis C that have cure rates exceeding 90 percent. In > 2015, the company's hepatitis C treatment sales peaked at $12.5 billion. > But as more people were cured and there were fewer infected individuals > to spread the disease, sales began to languish. Goldman Sachs analysts > estimate that the treatments will bring in less than $4 billion this > year. [Gilead]'s rapid rise and fall of its hepatitis C franchise > highlights one of the dynamics of an effective drug that permanently > cures a disease, resulting in a gradual exhaustion of the prevalent pool > of patients," the analysts wrote. The report noted that diseases such as > common cancers -- where the "incident pool remains stable" -- are less > risky for business./ > > > On 4/19/2018 11:02 PM, Rayilyn Brown wrote: > > Hi Trauti, > > > > I guess I have a negative feeling re all these PD meds. I've taken > > Rytary and Rimantadine for over a year now without trouble but no > > real help either. Wonder how the Tasigna trials are going. The > > powers that be have a big nerve preventing its approval for PD when > > so many approved PD meds have such dreadful side effects. Amantadine > > helped for about a month before all hell broke lose. I'm betting on > > the Rytary rather than PD progression because these are such powerful > > drugs. > > > > I not only hate getting worse but I can't fight so much anymore. > > > > -----Original Message----- From: Trauti Boyd > > Sent: Wednesday, April 18, 2018 4:12 AM > > To: [log in to unmask] > > Subject: Re: Nuplazid > > > > hi, ray! i'm not sure if amantedine is responsible for nic's > > hallucinations or a progression of pd. my husband is getting them more > > and more these days and the only pd medicine he takes are 2 rytary > > 61/245 per day. naturally, i have no way of knowing if the > > levodopa/carbidopa might be the cause of this. > > > > and yes - it's a hateful disease with no improvements in sight! :( > > > > > > On 4/18/2018 12:26 AM, Rayilyn Brown wrote: > >> how I hate this disease! do you get ANY good from these meds? > >> > >> -----Original Message----- From: Nic Marais > >> Sent: Monday, April 16, 2018 4:21 PM > >> To: [log in to unmask] > >> Subject: Re: Nuplazid > >> > >> Ray > >> > >> Any spot on the wall grows legs and start moving... :-) > >> > >> Visual hals are worse when I take my glasses off. > >> > >> I think what causes the hals is the brain trying to make sense out of > >> the > >> noise (Of running bathwater, flushing toilet, unfocused spots, dark room > >> with lots of shadows). Somehow Amantedine triggers this reaction. > >> > >> Something completely different; > >> > >> When I sit or stand in one position, I progressesively lean over to the > >> left. It's very suttle and drives my wife bonckers. Reading a book, I > >> catch > >> myself hanging on the table with my left hand, my head at an angle of > >> about 45 degrees to the book. The other night I actually fell out of the > >> chair... I suspect it is my lefthand back muscles. My left is more shaky > >> than my right. > >> > >> Regards > >> > >> Nic > >> > >> On Sat, Apr 14, 2018, 08:00 Rayilyn Brown <[log in to unmask]> wrote: > >> > >>> Nic > >>> > >>> Now I know what those conversations I hear in living room are. And I'm > >>> getting hard of hearing. > >>> > >>> After a month Amantadine really did I number on me, not so nice. > >>> Besides > >>> animals, monsters and dead people a thin saran-like substance was > >>> all over > >>> everything! my neuro said this substance was the most common > >>> Amantadine > >>> hallucination. and it helped me but I had to quit it, couldn't > >>> stand the > >>> hals. Have taken Rimantadine for over a year and except for one day > >>> when > >>> I > >>> thought I was seeing s mall black insects ive ben OK except it doesn't > >>> help > >>> much. nothing does > >>> > >>> -----Original Message----- > >>> From: Nic Marais > >>> Sent: Tuesday, April 10, 2018 5:20 PM > >>> To: [log in to unmask] > >>> Subject: Re: Nuplazid > >>> > >>> I guess I have to get used to all the animals and people in the > >>> house. They > >>> hide behind the bedroom curtains occasionally slipping a hand out and > >>> wave at me. > >>> > >>> They also sit on my bed and turn into big rats running on my bed > >>> cover. > >>> This is only the visual hals. The sound ones are the most difficult to > >>> judge if it's reality or a hal... I don't mind the music when I > >>> flush the > >>> toilet or run the bathWater. It's rather pleasant ;-) It's the > >>> whispers and > >>> conversations and loud bangs that is very disturbing at times' > >>> > >>> Anybody like to share their hals on the list? Should be interesting ;-) > >>> > >>> Nic 66/24 > >>> > >>> > >>> On Apr 10, 2018 8:08 AM, "Rayilyn Brown" <[log in to unmask]> wrote: > >>> > >>> yes, I saw this too > >>> > >>> > >>> -----Original Message----- > >>> From: Maryse Schild > >>> Sent: Monday, April 09, 2018 10:35 AM > >>> To: [log in to unmask] > >>> Subject: Nuplazid > >>> > >>> beware: > >>> > >>> > >>> > https://edition.cnn.com/2018/04/09/health/parkinsons-drug-nuplazid-invs/index.html > >>> > >>> > >>> maryse > >>> > >>> ---------------------------------------------------------------------- > >>> To sign-off Parkinsn send a message to: mailto: > >>> [log in to unmask] > >>> In the body of the message put: signoff parkinsn > >>> > >>> ---------------------------------------------------------------------- > >>> To sign-off Parkinsn send a message to: mailto: > >>> [log in to unmask] > >>> In the body of the message put: signoff parkinsn > >>> > >>> ---------------------------------------------------------------------- > >>> To sign-off Parkinsn send a message to: mailto: > >>> [log in to unmask] > >>> In the body of the message put: signoff parkinsn > >>> > >>> ---------------------------------------------------------------------- > >>> To sign-off Parkinsn send a message to: mailto: > >>> [log in to unmask] > >>> In the body of the message put: signoff parkinsn > >>> > >> > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > >> mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > >> mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > >> > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn