Confirms my long-held suspicion that big pharma is interested in marketing new treatments, not cures. And I thought I was just being cynical. Roger On Sat, Apr 21, 2018 at 1:14 AM, John < [log in to unmask]> wrote: > I found this interesting! Damn, ONLY $4 Billion! > > "In 2015, the company's hepatitis C treatment sales peaked at $12.5 > billion. > > treatments will bring in less than $4 billion this year." > > John, caregiver for Sue 5/13/2016, RIP > > > > > -----Original Message----- > >From: Trauti Boyd <[log in to unmask]> > >Sent: Apr 20, 2018 4:10 AM > >To: [log in to unmask] > >Subject: Re: Nuplazid > > > >hi, ray! you must have missed goldman sachs' recent analysis of a > >'one-shot cure' : > > > >/Analyst Salveen Richter and colleagues laid it out: "The potential to > >deliver 'one shot cures' is one of the most attractive aspects of gene > >therapy, genetically engineered cell therapy, and gene editing. However, > >such treatments offer a very different outlook with regard to recurring > >revenue versus chronic therapies... While this proposition carries > >tremendous value for patients and society, it could represent a > >challenge for genome medicine developers looking for sustained cash flow." > > > >For a real-world example, they pointed to Gilead Sciences, which markets > >treatments for hepatitis C that have cure rates exceeding 90 percent. In > >2015, the company's hepatitis C treatment sales peaked at $12.5 billion. > >But as more people were cured and there were fewer infected individuals > >to spread the disease, sales began to languish. Goldman Sachs analysts > >estimate that the treatments will bring in less than $4 billion this > >year. [Gilead]'s rapid rise and fall of its hepatitis C franchise > >highlights one of the dynamics of an effective drug that permanently > >cures a disease, resulting in a gradual exhaustion of the prevalent pool > >of patients," the analysts wrote. The report noted that diseases such as > >common cancers -- where the "incident pool remains stable" -- are less > >risky for business./ > > > > > >On 4/19/2018 11:02 PM, Rayilyn Brown wrote: > >> Hi Trauti, > >> > >> I guess I have a negative feeling re all these PD meds. I've taken > >> Rytary and Rimantadine for over a year now without trouble but no > >> real help either. Wonder how the Tasigna trials are going. The > >> powers that be have a big nerve preventing its approval for PD when > >> so many approved PD meds have such dreadful side effects. Amantadine > >> helped for about a month before all hell broke lose. I'm betting on > >> the Rytary rather than PD progression because these are such powerful > >> drugs. > >> > >> I not only hate getting worse but I can't fight so much anymore. > >> > >> -----Original Message----- From: Trauti Boyd > >> Sent: Wednesday, April 18, 2018 4:12 AM > >> To: [log in to unmask] > >> Subject: Re: Nuplazid > >> > >> hi, ray! i'm not sure if amantedine is responsible for nic's > >> hallucinations or a progression of pd. my husband is getting them more > >> and more these days and the only pd medicine he takes are 2 rytary > >> 61/245 per day. naturally, i have no way of knowing if the > >> levodopa/carbidopa might be the cause of this. > >> > >> and yes - it's a hateful disease with no improvements in sight! :( > >> > >> > >> On 4/18/2018 12:26 AM, Rayilyn Brown wrote: > >>> how I hate this disease! do you get ANY good from these meds? > >>> > >>> -----Original Message----- From: Nic Marais > >>> Sent: Monday, April 16, 2018 4:21 PM > >>> To: [log in to unmask] > >>> Subject: Re: Nuplazid > >>> > >>> Ray > >>> > >>> Any spot on the wall grows legs and start moving... :-) > >>> > >>> Visual hals are worse when I take my glasses off. > >>> > >>> I think what causes the hals is the brain trying to make sense out of > >>> the > >>> noise (Of running bathwater, flushing toilet, unfocused spots, dark > room > >>> with lots of shadows). Somehow Amantedine triggers this reaction. > >>> > >>> Something completely different; > >>> > >>> When I sit or stand in one position, I progressesively lean over to the > >>> left. It's very suttle and drives my wife bonckers. Reading a book, I > >>> catch > >>> myself hanging on the table with my left hand, my head at an angle of > >>> about 45 degrees to the book. The other night I actually fell out of > the > >>> chair... I suspect it is my lefthand back muscles. My left is more > shaky > >>> than my right. > >>> > >>> Regards > >>> > >>> Nic > >>> > >>> On Sat, Apr 14, 2018, 08:00 Rayilyn Brown <[log in to unmask]> wrote: > >>> > >>>> Nic > >>>> > >>>> Now I know what those conversations I hear in living room are. And > I'm > >>>> getting hard of hearing. > >>>> > >>>> After a month Amantadine really did I number on me, not so nice. > >>>> Besides > >>>> animals, monsters and dead people a thin saran-like substance was > >>>> all over > >>>> everything! my neuro said this substance was the most common > >>>> Amantadine > >>>> hallucination. and it helped me but I had to quit it, couldn't > >>>> stand the > >>>> hals. Have taken Rimantadine for over a year and except for one day > >>>> when > >>>> I > >>>> thought I was seeing s mall black insects ive ben OK except it doesn't > >>>> help > >>>> much. nothing does > >>>> > >>>> -----Original Message----- > >>>> From: Nic Marais > >>>> Sent: Tuesday, April 10, 2018 5:20 PM > >>>> To: [log in to unmask] > >>>> Subject: Re: Nuplazid > >>>> > >>>> I guess I have to get used to all the animals and people in the > >>>> house. They > >>>> hide behind the bedroom curtains occasionally slipping a hand out > and > >>>> wave at me. > >>>> > >>>> They also sit on my bed and turn into big rats running on my bed > >>>> cover. > >>>> This is only the visual hals. The sound ones are the most difficult to > >>>> judge if it's reality or a hal... I don't mind the music when I > >>>> flush the > >>>> toilet or run the bathWater. It's rather pleasant ;-) It's the > >>>> whispers and > >>>> conversations and loud bangs that is very disturbing at times' > >>>> > >>>> Anybody like to share their hals on the list? Should be interesting > ;-) > >>>> > >>>> Nic 66/24 > >>>> > >>>> > >>>> On Apr 10, 2018 8:08 AM, "Rayilyn Brown" <[log in to unmask]> wrote: > >>>> > >>>> yes, I saw this too > >>>> > >>>> > >>>> -----Original Message----- > >>>> From: Maryse Schild > >>>> Sent: Monday, April 09, 2018 10:35 AM > >>>> To: [log in to unmask] > >>>> Subject: Nuplazid > >>>> > >>>> beware: > >>>> > >>>> > >>>> https://edition.cnn.com/2018/04/09/health/parkinsons-drug- > nuplazid-invs/index.html > >>>> > >>>> > >>>> maryse > >>>> > >>>> ------------------------------------------------------------ > ---------- > >>>> To sign-off Parkinsn send a message to: mailto: > >>>> [log in to unmask] > >>>> In the body of the message put: signoff parkinsn > >>>> > >>>> ------------------------------------------------------------ > ---------- > >>>> To sign-off Parkinsn send a message to: mailto: > >>>> [log in to unmask] > >>>> In the body of the message put: signoff parkinsn > >>>> > >>>> ------------------------------------------------------------ > ---------- > >>>> To sign-off Parkinsn send a message to: mailto: > >>>> [log in to unmask] > >>>> In the body of the message put: signoff parkinsn > >>>> > >>>> ------------------------------------------------------------ > ---------- > >>>> To sign-off Parkinsn send a message to: mailto: > >>>> [log in to unmask] > >>>> In the body of the message put: signoff parkinsn > >>>> > >>> > >>> ---------------------------------------------------------------------- > >>> To sign-off Parkinsn send a message to: > >>> mailto:[log in to unmask] > >>> In the body of the message put: signoff parkinsn > >>> ---------------------------------------------------------------------- > >>> To sign-off Parkinsn send a message to: > >>> mailto:[log in to unmask] > >>> In the body of the message put: signoff parkinsn > >>> > >> > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > >> mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > >> ---------------------------------------------------------------------- > >> To sign-off Parkinsn send a message to: > >> mailto:[log in to unmask] > >> In the body of the message put: signoff parkinsn > >> > > > > > >---------------------------------------------------------------------- > >To sign-off Parkinsn send a message to: mailto:[log in to unmask] > utoronto.ca > >In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > utoronto.ca > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn