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Hi Everyone, Happy New Year! SOCAAR is pleased to announce our first SOCAAR Seminar for 2024: Please join us Online on: Wednesday, Jan 17, 2024 3:00PM - 4:00PM EST 3:00PM - 4:00PM EST Dr. Errol Thomson Research Scientist Inhalation Toxicology Laboratory, Health Canada Department of Biochemistry, Microbiology & Immunology, University of Ottawa From biological plausibility to predictive models: air pollution, stress, and determinants of toxicity Abstract: When epidemiological studies first showed compelling evidence of associations between ambient levels of fine airborne particles and increased cardiopulmonary mortality, toxicologists were challenged to assess their biological plausibility. It is now generally accepted that air pollution is one of the top risk factors for mortality worldwide. However, associations between exposure to air pollutants and an ever-increasing range of adverse health outcomes – including dementia, depression, obesity, diabetes; all conditions with a substantial and growing population prevalence - continue to raise mechanistic questions. Moreover, the spatial and temporal variability of air pollution poses challenges in identifying key determinants of toxicity that would allow us to move beyond mass-based standards. This seminar will describe work establishing how the body’s stress response system – essential for survival but deleterious when chronically activated – acts as a key mechanism underlying systemic effects of air pollution on health. It will then describe how toxicological tools are being applied to link biological effects to pollutant composition, and hence source. Finally, it will provide examples of how use of more human-relevant toxicological tools, and translation of toxicological findings to the population, may help us to better understand factors underlying susceptibility and identify toxicity determinants. ________________________________________________________________________________ Microsoft Teams meeting Join on your computer, mobile app or room device Click here to join the meeting<https://teams.microsoft.com/l/meetup-join/19%3ameeting_ZWMwMDdhMDEtMGQyOS00ODU1LThlZTYtZjQwZWFmNmE4OTc1%40thread.v2/0?context=%7b%22Tid%22%3a%2278aac226-2f03-4b4d-9037-b46d56c55210%22%2c%22Oid%22%3a%2276a2f469-c5cc-446a-8132-c4bf6f5856ed%22%7d> Meeting ID: 233 093 576 326 Passcode: bx4p6H Download Teams<https://www.microsoft.com/en-us/microsoft-teams/download-app> | Join on the web<https://www.microsoft.com/microsoft-teams/join-a-meeting> Or call in (audio only) +1 647-794-1609,,67023358#<tel:+16477941609,,67023358#> Canada, Toronto Phone Conference ID: 670 233 58# Find a local number<https://dialin.teams.microsoft.com/d82c5eb5-d575-428c-bac3-869ecf09d547?id=67023358> | Reset PIN<https://dialin.teams.microsoft.com/usp/pstnconferencing> Learn More<https://aka.ms/JoinTeamsMeeting> | Meeting options<https://teams.microsoft.com/meetingOptions/?organizerId=76a2f469-c5cc-446a-8132-c4bf6f5856ed&tenantId=78aac226-2f03-4b4d-9037-b46d56c55210&[log in to unmask]&messageId=0&language=en-US> ________________________________________________________________________________