Dear Ed H; Thanks for your thoughts on exercise and medication dosage. I have not seen the Prodigy pieces on exercise. Could you forward me the one by Will Johnston? I have cut back some due to fatigue that visits me about 11:00 in the morning and 3:00 in the afternoon. I have found that it I lie down on the floor of my office and meditate or nap for about 15 min each time, I can go right back to my work. I have to be really careful not to over do the yoga and nautilus. One of my graduate students is a trainer for nautilus and he has been working with me; that has been very helpful in setting the right pace. I am interested in your medication dosage. You are taking what I have been taking this year. My neurologist started me out on 25/100 sinemet 3x for the first two months. Then she added 5 mg. deprenyl 2x. I had read that most start these in reverse order. At 4 months she wanted me to go to 4x which I did for a month and then went back to 3x. And a month or two later, I went back to 2 1/2 x. That was too little; symptoms came back. I went back to 3x and stayed there til about 3 wks ago when I developed some muscle twitching in the left hand at rest in the evening when I went to bed. I went to 4x with the 4th in the 11-12 hour at night. That stopped the twitching. I went back to 3x for 4 days and now am back to 3x. Everything is now stable again. Do you have any reactions to this? I am impressed that you can vary the medication so much (1-4) without any noticeable difference, and that you are on this low a level. Sounds as if they take the edge off the symptoms, but that you still have them even with medication. Thanks. Bob N.Z