Dear Ed: I started this message our incorrectly so you may see some of it in the wrong place. Thanks for the introduction and information. It really helps to get acquainted a bit through this faceless contraption. I am quite interested in the course of your reactivity to the medication over time. I am on the same dosage of the two as you and this being my first year, most of my symptoms receded so long as I maintain them. But I wonder what I have to look forward to. I'd appreciate learning what it has been for you. I understand that some physicians wait to prescribe sinemet after the diagnosis on the theory that it will prolong the period of time what the meds will be effective. As I said earlier, I was started right out, bang. And within a day, I was worlds improved. And since then, that has maintained. But that has been only 11 months. Thanks again. Bob N.