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Dear Barbara, Re:sinemet reaction. I tried to send this info yesterday unsuccessfully so once more> At the initial diagnosis 1989, the neurologist prescribed sinemet. That evening, probably with a meal I took the first half pill dose. My throat felt as though it was closing, I developed mild abdominal cramping which was annoying enough to keep me awake all night, and leg cramps. I called the dr. in the a.m. and he said discontinue. Now 4 years later I am taking it. Doctors ever since had been afraid to prescribe it but after dancing around it, with nowhere else sensible to go, Dr. Hurtig, chief neurologist of the Movement Disorder Clinic, at Graduate Hosp., Phila. started me out thusly. The first dose was to be one QUARTER of 25/100 in the a.m. with FOOD. I was to keep at this level for two weeks. Next increment was another QUARTER at noon again for two weeks. Third increment a QUARTER with food always in evening. Then I started again at the breakfast with a half this time. Somewhere along the way, I again developed the closing throat so I had to hold the same dosage and back off the increment for a month or so. Finally, about four months later, I am still at A HALF three times a day. The heavy doses of bromocriptine I was on then had to be reduced, again very slowly, in this case, one half a tablet reduction every two weeks. From 5 and 1/2 tabs. of that five times a day, I am now down to one. Just this week I was advised to add another quarter of the Sinemet. However, a week ago today I accidently overdosed on both Sinemet and Parsitan. In the case of the Sinemet, it equalled a whole tablet. I had the feeling I was going to pass out, listed to the left and then the throat business closed in. I knew that was the Sinemet. Long story short, I survived by pacing the malls, drinking coffee, etc. Didn't want to go to a hosp. because of complexity. Anyhow, these medicines are potent; anything which affects the central nervous system must be. I called my intro to Sinemet the bee venom sensitivity doses. HOpe this helps. At least you know you are not the only one to get in trouble. Sergio, I wonder how you are. How did you ever write from a hospital bed. Think of you often and in prayer. Will chat more later. Lucile Wright [log in to unmask]