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Dear Barbara Patterson - I was sorry to read about your reaction to sinamet. I hope by the time you read this that your system has begun to adapt to the drug as it is pretty well accepted as the No.1 medication to alleviate PD symptoms. Personally, I take 3 25/100 pills daily along with 2 5gr eldepryl and only on rare occasions have I encountered a slight nausea. On those occasions lying down for a short nap abated the feeling......ED H Dear Barbara Yacos - I believe the 'unknown' you refer to is from Internet telling you that it can't find the address you gave it. Evidently you gave it another one that it could find because here you be.....Welcome! PS (and no explosions).......ED H