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I am writing this message on behalf of my father, Alan, who has Parkinson's disease. I subscribed on his behalf and have been pulling down the monthly Log files and sending them to him for the last two months. On Jan 25th, there was a message giving some information from a book by Lieberman- Parkinson's Disease: The Complete Guide For Patients and Caregivers. In information on Chapter 4, - Understanding Drug Therapy, the text says: "Sinamet should be taken 1 hour before meals for maximum benefit with one whole glass of water or juice" My father, who lives in England, has been told to take his Sinemet at certain times during the day, not specifically before or after meals. He takes two tablets when he gets up at about 7.00a.m., he has breakfast at about 8.00a.m. He has lunch at about 12.30pm, takes three more Sinemet at 3.00pm, has dinner at about 5.00pm, and then takes two more Sinemet at about 10.00pm. He has not been specifically advised that water should be taken with the tablets. Is it likely that there could be a significant benefit derived from making a change in how he is taking the drug. We would be grateful for comments. Phil Roeper