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Dear Keith VanDenburg: Welcome to the conversation. I am interested in your medications history. How long have you been on this particular regimen? Did you start with less, and work up I haveeen on mine for about a year: 20/100 Sinemet at 6:00, 12:00, 6:00 and 5 mg Eldepryl at 8:00 and 1:00. That has worked well to date, but I am noticing an increase in stiffness and sore- ness in my shoulder muscles, and a slight gait and balance problem over the past month and I am expecting to have to increase soon. Anyway, I'd appreciate knowing more how it has been for you. Bob Newbrough ([log in to unmask] vanderbilt.edu).