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I recently started taking Sinemet 100/25 three times a day in addition to Selegiline (Deprynil) 5 mg twice a day. After having an initial problem adjusting to the Sinemet, I felt physically well for the first time in ages. Over the past few weeks, I have noticed my left foot is twisting..I end up walking on the outside edge of it with my big toe sticking up...not the most comfortable thing. I phoned the neurologist last Tuesday and she said to cut back on the Sinemet to two a day and scheduled an appointment for Tuesday, May 3. She said it could either be the drug or PD which is causing this and by cutting back on Sinemet for a week she would know which it was. Now I am, once again, having a reaction to the second Sinemet of the day...dizzy, cold sweat, etc....my foot is still twisting and I much prefer the way I feel on three a day. I take the first Sinemet at breakfast and tried taking the second one in the middle of the afternoon because I was tired before my work day was over. Any ideas or suggestions?