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I also have muscle cramps in the muscle in the top of my left leg but I've had these for a few years. They seemed to be a bit better when I first started on Sinemet but now they are annoying again. I have had one or two experiences with my left eyelid twitching but that has happened for years whenever I get overtired and overstressed. My family doctor seemed to think that, and the jaw-clenching, were related to the stress and depression. I am on a very low dose of Amitryptiline (sp?) to help me sleep. I think that one of the things I am going to do is make a list of all of the drugs that I am on and take it with me to the neurologist. With my family dr., the neurologist and the gynecologist all involved in prescribing meds to improve my life, I think there may be one or two pills too many. Five years ago I was on NO meds at all...never even took aspirin. I'll let you know what happens. Thanks for the information. Barb.