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Hello PD club After reading the coments in regards to the twisting foot, I wish to add my thoughts. I also have this effect. My twisting foot shows up when the level of sinemet is low. My reading of Barb Y. and Alan B., coments seem to be different in that of a overdose condition. Refering to "Parkinson's Disease The complete guild..." pages 135-137 Dystonia, a tented hand, a turned-in foot, a twisted trunk Dyskinesia, a rhythmic movement. on page 137--"Dystonia can occur as a symptom of the disease itself or as a side effect of levodopa therapy." next paragraph " Treatment: If you experience dystonias, keep track of when they occur. Is it before your medician takes effect or after? If it's before Sinemet kicks in, your physician will probably either increase the amount levodopa you take or have you take smaller doses more often. If your dystonia is a side effect of levodopa therapy your doctor may reduce the amount of sinemet you take, perhaps adding a dopamine agonist to make up the difference in anti-Parkinson effects." In my case the twisted foot comes on when a lack of levodopa occures My over dose effects show as dyskineas, rhythmic movments. My Parkinson's condition is more of the shaking tremor effect. I was controlling this with Sinemet, but the amounts used, kept me in the dyskinesia problem area. I am now using Cogentin 1mg 3x a day and have cut back on Sinemet to 4 each of 50/200 cr a day. This helps to control the shaking and reduces rhythmic movements. " Cogentin - anticholinergic blocks the action of acetylcholine, thereby rebalancing it in relation to dopamine and reducing rigidity and tremor." page 257 see also page 55. So what's what, to much or more needed ? Interesting, this parkinson disease. Keith