Jackie, I find the reaction of your neuro perplexing, and feel that maybe you should consider another opinion on the diagnoses of your husband. The age old question of what is the difference between a "Disease" and a "Syndrome" goes on, and is as near a resolution as there are people that KNOW THEY know the difference. Everyone that gets sucked into this debate are sure they have the "right' answer. Actually, in my research of Parkinson's, I have yet to find a clear definition between the two ...if in fact, there is one.. I have found that the two descriptors are used interchangeably, depending on the culture and/or Medical School attended, which leads me to think that a rose, is a rose, is a rose - by any other name. I have researched Parkinson's for over 16 years, and have talked to most of the major players involved in active research on Sir James Parkinson's "Shaking Palsy". People like Dr. Joseph Knoll (the formulator of selegiline hydrochloride), Drs. Walther and George Birkmayer (the first to use L-dopa on humans), Dr. Langston (of MPTP fame), and too many others to relate here. The point is that I have yet to find or hear a valid description of any difference. To complicate the matter there is also "essential tremor" and "super-necular palsy" looming over the horizon. Often, I think, "Essential Tremor" is a doctorese diagnoses for "I don't know what the hell you have and I don't want to call it Parkinson's." The above mentioned research was because of two things: 1. I have Parkinson's ....whatever. 2. I was a prime researcher for my wife's book, "Parkinson's Disease: The Mystery, The Search and The Promise" by Sue Dauphin. ISBN # 0-9620354-1-6, LibCong# 92-093912 Sinemet is a good drug, but the effect can eventually "diminish". There is also a form of sinemet called sinemet CR (controlled Release). I would also ask your husband's doctor about Eldepryl (selegiline hydrochloride) as it has been shown to slow the onset of Parkinson's in a nation-wide test called DATATOP. Just remember, Parkinson's is not the end of life. It is the beginning of a new way of life. I hope this has helped, Jackie. I wish you and your husband the very best, VernD Note to other readers of this post: I will not engage in a fruitless debate on the difference between a "disease" and a "syndrome". There is much, too much, other important information out there to talk about. Thank you.