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---1678269084-1638217601-771645609:#17948 Content-Type: TEXT/PLAIN; charset=US-ASCII ---1678269084-1638217601-771645609:#17948 Content-Type: APPLICATION/octet-stream; name="caber.mail" Content-ID: <[log in to unmask]> Content-Description: I am a 60 year old physician with Parkinson's Disease of 7 years. Thus far I have noted only miniscule or no benefits from available medications. For the past 10 weeks I have taken gradually increasing doses of cabergoline, starting with 0.5 mg and now up to 5 mgm/day (maximum allowed). I have experienced peculiar aching sensations. These were mild at first and temporary but lately have increased in intensity and persistence. The ache is mainly in the left shoulder, the left anterior and posterior hemithorax (front and back of the left chest), the neck, the left upper arm (antero-lateral) and sometimes the left upper inner arm. There are episodic pains in the left flank, right buttocks, and right calf. The neck, chest, and shoulder pain are aggravated by bending and raising the neck, and also with neck rotation. Coughing may sometimes worsen pain. Interestingly, the pain is often lessened by elevating the left arm. All the pain ceases in bed if I lie still on my back (supine) or on my right or left sides (decubitus position). The pain is exacerbated on arising and stretching (to put on socks) or bending. The pain is associated with temporary weakness of the arms and hands, i.e., pulling, pushing. There is no loss of sensation, numbness or tingling. My appetite is good. I started to keep a diary in March, 94 when I began the cabergoline. I am not sure if the pain began before or after the use of the medication. My concern is, could this pain be drug-related. Stopping the medication should of course answer the question but this may be premature. The drug investigators want me to continue. I would appreciate the apparent problems that others may have experienced and especially if anyone has had a peculiar musculo-skeletal symptom like mine. ( It would be premature to indict the cabergoline at this time, and the symptoms may be unrelated to the illness or the medication). Thank you for your replies. - Julian Mayro ---1678269084-1638217601-771645609:#17948--