 |
 |
On Mon, 13 Jun 1994, Joanna Porvin wrote: > Has anyone had personal experience with any of this research, especially > regarding the new dopamine agonists (Cabergoline, Ropinerole or > Pramipexole) or the COMT blocker Tolcapone? Or does anyone have further > information or references regarding these studies? > > If so, please post to the group. The following are some recent references: CABERGOLINE (The first by Dr Lieberman and his team): ---------------------------------------------------------------------- Lieberman, A., Imke, S., Muenter, M., Wheeler, K., Ahlskog, J.E., Matsumoto, J.Y., Maraganore, D.M., Wright, K.F. and Schoenfelder, J. Multicenter Study of Cabergoline, a Long-Acting Dopamine Receptor Agonist, in Parkinson's Disease Patients with Fluctuating Responses to Levodopa Carbidopa. Neurology 43:1981-1984, ---------------------------------------------------------------------- Lera, G., Vaamonde, J., Rodriguez, M. and Obeso, J.A. Cabergoline in Parkinsons Disease - Long-Term Follow-Up. Neurology 43:2587-2590, 1993. ====================================================================== Recent publications on TOLCAPONE: Roberts, J.W., Coralocatelli, G., Bravi, D., Amantea, M.A., Mouradian, M.M. and Chase, T.N. Catechol-O-Methyltransferase Inhibitor Tolcapone Prolongs Levodopa Carbidopa Action in Parkinsonian Patients. Neurology 43:2685-2688, --------------------------------------------------------------------- The following references deal with Tolcapone used in experiments with rats: Tornwall, M. and Mannisto, P.T. Effects of Three Types of Catechol O-methylation Inhibitors on L-3,4-dihydroxyphenylalanine-Induced Circling Behaviour in Rats. Eur J Pharmacol 250:77-84, 1993. ---------------------------------------------------------------------- Tornwall, M., Tuomainen, P. and Mannisto, P.T. Modulation of Rat Brain Endogenous Dopamine Metabolism by New Inhibitors of Catechol O-Methyltransferase. Eur J Pharmacol 239:39-45, 1993. ---------------------------------------------------------------------- Hans===================================================================== Hans van Zyl | Cell Physiology Group | [log in to unmask] Irene Animal Production Institute | Tel: (27) 12 672 9261 Private Bag X2 | Fax: (27) 12 665 1604 IRENE 1675, South Africa | =====================================================================