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The only drugs I am taking for pd are Sinamet and Deprynil. I am also taking amitryptiline. I think that the foot twisting is part of pd rather than a side effect of a medication. Long before I was diagnosed with pd, I noticed that the heel of my left shoe would be worn down long before the right shoe. What I am experiencing lately is the same sort of thing only worse. I really appreciated the suggestion about keeping a chart documenting when meds are taken and when the foot twisting starts but I am FAR from being that organized. Besides, the only time I know my foot is twisting is when the side of my foot gets sore and now, with the cane, I am more aware of the position of my foot. It never occurred to me to wonder what happened to the carbidopa...now I, too, would like to know. Barb