Hello Leif and welcome. I've been on the list for about 6 months and I think this is only the third time I've sent a message. I have the same questions that you do so maybe we can spur some more responces from the rest of the young onset folks out there. My symptoms started about when I was 28 in 1988. I was diagnosed in 1990 and started on Sinemet. My initial symptom was a tremor and some stiffness in my left hand and by the time I was diagnosed I was experiencing some problems with my left foot when I walked. During the 5 or so years since then I have been working with my neurologist on trying to lengthen my "on" periods. I am currently taking: 1 25/100 Synemet + 1 50/200 Synemet CR + 3 5mg Parlodel Three times a day 1 5mg Eldypril Twice a day (This new schedule will have to be trimmed back. We were hoping that the parlodel would lengthen the effect but it just makes me "shacky") I have noticed for about the last 6 months that during my "off" times I have stiffness in my right hand. I have never had any tremor on my right side as of yet. I often wonder that since my symptoms are unilateral, and the drugs certainly aren't, wether this symptom is the progression of the disorder or just a dependence my body has developed after taking Synemet for 5 years. Well, I've tried to curb my tendency to be very "longwinded" when I write. I don't think I've been very successful. My condition has not stopped me from doing anything that I used to do. I was never an extremely active person. My job and my hobby is computing and I hope to continue for quite some time. My spirits have been much improved since I got on the list here and started hearing about some of the promising research. Hope this info helps. Hope to hear from some other "youngster". Roy Lee ([log in to unmask])