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Thanks for replying to my post.  I'm not sure I am proficient enough in
biochemistry to understand the reasons that you now need a drug holiday.
Am I correct in presuming that the liquid form causes your body to
produce more COMT and that the L-dopa wasn't making it into the brain?
Can you give a little biochemical background here?  (And are you finding the
"holiday" effective, if uncomfortable?)
 
Thanks.
Joanna
 
 
On Mon, 8 Aug 1994 [log in to unmask] wrote:
 
> Be careful with this stuff.  It is a good and effective delivery system.  Too
> good.  After using liquid sinemet for the major part of this year,  I am at
> the point where the (COMT) catechol-O-methyl transferase in my blood was
> metabolizing the levodopa as it passes toward the brain, and am now having a
> sinemet drug holiday (substituting Permax for sinemet) until my body can
> clear itself of COMT.  IT is not my idea of fun.  If you are using liquid
> sinemet, use in very discreet moderation ...or better still, stick with the
> "hard stuff".
> VernD
>