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My wife Lynn Kidd has used Baclofen to reduce muscle spasm in her right foot, especially her toes. She takes a minimum dose (low side of therapeutic levels) of 10 mg at night and morning. She has been taking the medication for about 5 years and has decreased the dosage to this level from a previous 45 mg per day. Her spasm has decreased over the years, thankfully. She doesn't take the sinemet at night. _______________________________________________________________________________ Subject: Baclofen Author: Parkinson's Disease - Information Exchange Network Has anyone used the muscle relaxant BACLOFEN (Lioresal) for leg spasms or foot cramps? I know it is used for MS as well as spinal cord injuries - but what about PD? I save one of my 3 daily doses of Sinemet CR 25/100 for the inevitable spasms and cramps or Restless Leg Syndrome which comes at bedtime, but I would rather use the Sinemet during the day - for sure I don't want to add a 4th dose at bedtime as I'm trying to keep the daily dosage as low as possible. Your input for or against is appreciated. Barbara Yacos <[log in to unmask]>