Matt Klompstra, I read with great empathy and understanding your description of your dad's Parkinsonian condition. I am 46, soon to turn 47 and I have had Parkinson's for the last 13 years. I believe there is great hope I can offer you through a surgical procedure known as a Pallidotomy. I had a bilateral Pallidotomy last Dec. 1, and it has absolutely changed my life. I am back doing many physical activities I enjoyed before such as skiing, playing tennis and golf, plus some I never dreamed I would be able to do such as sky diving, and hang gliding. In regards to the depression your dad can no doubt obtain some relief by taking a serotonin uptake inhibitor such as Paxil or Zoloft. Seratonin has been found to be as deficient as dopamine in Parkinson's patients. If you want more information on the Pallidotomy check the archives on the Parkinson digest through this past summer or I would be glad to send you further info. A very thankful recovered Parkinsonian, Don Berns <[log in to unmask]>