Hi, I'm a parkinsonian. My name is Phyllis Riely. I have had some of the reactions your father had experienced. Was he on Sinemet-CR (sustained release)? I take 8 Sinemet CRs and 4 Sinemet 25/100s a day. My throat tightens up and the reaction is dyskinesic in character with a chewing and shallowing problem. I don't experience this reaction at every dose, but it occurs often. I notice this reaction more when I am tired, and my dieuretic isn't working well. I often get either constipation or diahrria. I have some thoughts as to its cause: - a build up of Sinemet in the body - Sinemet moving thru the gastrointestinal tract I have reprints of articles that may help you. If you would like them please send me your address directly to: Phyllis Riely 13373 N. Plaza Del Rio Bl Apt 7738 Peoria AZ 85381 ------------------------------------------------------------------- Sent on behalf of Dr. Riely by: ========================================================= FROM---------->> A.J. CONOVALOFF --------------------------------------------------------- Interests: PSP - Progressive Supranuclear Palsy Coordinator: PSP Arizona Support Groups --------------------------------------------------------- Postal Address: 10429 N. 105 Dr, Sun City AZ 85351-4418 Telephone: (602) 792-7828 Fax: none E-mail: [log in to unmask] =========================================================