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You are correct in that the fluctuations that PD patients develop are more a function of the ongoing disease process than the levodopa dose. Sinemet CR 50/200 and two 25/100 tablets cannot be equated. The lower dose is best used for patients who want small effects. :-) On Sun, 20 Nov 1994, Edward Huschka wrote: > AVFerriss - I have heard that the effects of Sinamettend to diminish > with time . Anywhere from 5 to 25 years as the time period. At a > recent symposium I asked the representative about this as I have > beentaking the drug for some 10 years. His response was that sometimes > side effects become a problem with persons who have graduated to extra > large dosages. I personally believe that the lessening effects (if > present) are due to the dying of the Dopamine producung cells ( The > Substancia Nigra) which accompany the aging process. Now, I have a > question. I was told that a single 50/200CR pill is the same as 2 > 25/100CR pills. I agree that the dosage is equal but is the time > effect the same? Do they dissolve at the same rate? For instance, 2 > small ice cubes melt completely in less time then one cube twice the > size of one of the smaller ones. If this is so, does the 50/200CR > release over a longer time period at a lesser rate. Do both variations > furnish the same doseage under these conditions or does one level off > at a higher peak for a shorter time span?.......EKH >