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EKH asked the following question: " I was told that a single 50/200CR pill is the same as 2 25/100CR pills. I agree that the dosage is equal but is the time effect the same? Do they dissolve at the same rate? For instance, 2 small ice cubes melt completely in less time then one cube twice the size of one of the smaller ones. If this is so, does the 50/200CR release over a longer time period at a lesser rate. Do both variations furnish the same doseage under these conditions or does one level off at a higher peak for a shorter time span?."......EKH I should know the answer to that, but unfortunately I do not. I will find it as quickly as possible and let you know. Best regards, Joe Irr, Worldwide Product Manager Sinemet Brand