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Further to recent discussion, my wife, Margaret, underwent an experimental course of treament some two years ago. For the trial she was hospitalised. Her dosage of Sinemet was stopped, and her other medications, Artane and Parlodel were reduced. This rendered her rigid and unable to move. After two days of this almost cold turkey treatment, she was given about 5ml ( I think it was) of Apomorphine by subcutaneous injection. About 15 minutes later, the specialist neurologist running the trial, said " Margaret, get up and walk" . And she did... a little shakily but completely unaided, and without using the walking frame she normally used. Truely, we thought the age of miracles hadn't passed. However, further administration of Apomorphine showed the same dyskinetic side-effects that have limted Margaret's daily Sinemet intake to 150 mg. (She takes this in three doses of half a 100/10 tablet after meals because she has found it causes less dyskinesia that way.) The test showed that there was a rapid dramatic initial effect, but that even with continuous infusion (using a modfied insulin pump), to be effective, the dose had to be increased to a point where dykinesia was unavoidable in her case. The only real advantage compared to Sinemet, in Margaret's case was the rapidity and certainity of response, but this was more than counterbalanced by the inconvenience of subcutaneous injection, to say nothing of the expense ( I think the daily cost of the quantity of the drug used, the actual tab was picked up by our health-care system, thank goodness, was between $50 and $100.) Take Care, Mark