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Thanks Joe - I appreciate the effort to provide a correct answer. It is pretty much as I expected but now I have it straight from the source... Actually if I desire to speed up reaction time for the 25/100CR I take 1/2 of a regular 25/100 along with it....EKH > Several weeks ago EKH asked if anyone knew if there would be a difference in > an individual's response to the drug if they took two Sinemet CR 25/100 > tablets instead of one 50/200 Sinemet CR tablet. > > I volunteered to find that answer and, although a little slow in coming, here > it is. I interviewed the physician who did most of the clinical research on > Sinemet CR prior to its approval for widespread use. > > He tells me that there should only be a very minor difference between use of > one 50/200 and two 25/100 Sinemet CR tablets. He said that if a patient is > OFF at the time the meds are taken, the two lower dose tablets might provide > sufficient levodopa just a few minutes sooner than the larger tablet. So, if > used first thing in the morning, ON may arrive a few minutes sooner. > > He wants to emphasize, however, that the difference is quite variable and of > short duration. He also said to remind Sinemet CR users that the duration of > the response should be the same no matter which tablets are taken. > > I hope this is useful information for you EKH and any other CR users. > > Best regards, > Joe Irr ([log in to unmask]) > --