Howard: I cannot comment on the eldepryl, but I have seen people who get the "tightening in the throat" symptom. If this feeling is intermittent, and appears to be related to his drug cycle, this may be a mild sort of dyskinesia of the larynx. In fact, someone else on this list discussed this problem not too long ago. It is probably not related to his arthritis, and perhaps not to his Parkinson's disease, per se. Instead, it may be related to the medications. The 2 people I know who have had this problem had their medications adjusted (reduction in Sinemet), and the laryngospasms went away. I hope this information helps. Nancy Solomon