I have a question about an issue that I don't believe has been discussed here before. My mother has been taking sinemet (I forget the dosage) for four months now and has received no noticeable benefit from it. From everything I have read, the effects of sinemet are generally quite noticeable and relatively immediate (i.e., you see an effect within a few hours). Her doctor has told her to just give it more time and she is continuing to take it since it also is not having any bad effects either. So my question is... are there some people for whom sinemet does absolutely nothing? Her only other medications are eldepryl and estrogen. Is it possible that her diagnosis with PD was incorrect? She has seen two neurologists with the same diagnosis. Also, her symptoms are the "classic" PD symptoms so we have never really questioned the diagnosis. But now I am starting to wonder. I thought sinemet had some effect for all PD patients. Needless to say, we are very disappointed at the (lack of) results. Thanks in advance for any insights. --Ann Strozewski