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Dear Brian: Your story about your father is interesting to me. I'm 60 and was diagnosed about 2 yrs ago. At that time, I was very very anxious and afraid and depressed; I was withdrawn and was ready to retire. After starting Sinemet, my mood lifted and within a fairly short time, I was back to my former level of confidence. The last two years, I have gone back to work as the old me. One of my students told me this week that dopamine related medications often are mood elevators and are used for mental health treatment as well as PD. I am interested in what symptoms your father has that are seen as dementia; is it forgetfulness? There is an involutional aspect of depression that looks like memory loss because the person goes so effectively "inside." I will be interested in knowing whether the Sinemet has any effects on the mentation. All the best. Bob Newbrough Question to the networkers: The medication mentioned above is Wellbutin. It is called a dopamine enhancer and is used in mood disorders. Has anyone knowledge of this drug? Is it used in treatment of PD?