Bob: Here is the result of a MEDLINE search on Wellbutrin (Bupropion)
and Parkinson's Disease. This is all there was. The last article is an
animal model only.
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?find parkinson and bupropion
9892 PARKINSON
272 BUPROPION
S1 5 PARKINSON AND BUPROPION (Wellbutrin)
?type s1/l/all
1/L/1
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
08788150 94103150
Acute delirium and parkinsonism in a bupropion-treated liver
transplant
recipient [letter]
Strouse TB; Salehmoghaddam S; Spar JE
J Clin Psychiatry (UNITED STATES) Dec 1993, 54 (12) p489-90,
ISSN
0160-6689 Journal Code: HIC
Languages: ENGLISH
Document type: LETTER
JOURNAL ANNOUNCEMENT: 9404
Subfile: INDEX MEDICUS
Tags: Case Report; Human; Male
Descriptors: *Buspirone--Adverse Effects--AE; *Delirium
--Chemically
Induced--CI; *Liver Transplantation; *Parkinson Disease,
Symptomatic
--Chemically Induced--CI; Depressive Disorder--Drug Therapy--DT;
Dystonia
--Chemically Induced--CI; Middle Age
CAS Registry No.: 36505-84-7 (Buspirone)
1/L/2
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
08138379 92276379
Falling backward in two elderly patients taking bupropion.
Szuba MP; Leuchter AF
Department of Psychiatry and Biobehavioral Sciences, University
of
California, Los Angeles School of Medicine.
J Clin Psychiatry (UNITED STATES) May 1992, 53 (5) p157-9,
ISSN
0160-6689 Journal Code: HIC
Contract/Grant No.: T32MH17140, MH, NIMH
Languages: ENGLISH
Document type: JOURNAL ARTICLE
JOURNAL ANNOUNCEMENT: 9209
Subfile: INDEX MEDICUS
BACKGROUND: Bupropion, a novel antidepressant, has been reported
to
produce fewer adverse effects than the tricyclic antidepressants. It
has
relatively weak effects on norepinephrine and serotonin reuptake
but
possesses significant dopamine agonist and reuptake blocking
effects.
METHOD: The case histories of two geriatric patients treated with
bupropion
for major depression are presented. RESULTS: Both patients
experienced a
previously unreported side effect--falling backward--associated
with
bupropion use. Orthostatic hypotension and vertigo are not consistent
with
the patients' histories. Both patients manifested other symptoms
consistent
with parkinsonian syndrome. CONCLUSION: This side effect, apparently
unique
to bupropion among antidepressants, may be mediated through
dopaminergic
effects in the basal ganglia. Clinicians should be alert to these
potential
problems in the geriatric population.
Tags: Case Report; Female; Human; Support, U.S. Gov't, P.H.S.
Descriptors: *Bupropion--Adverse Effects--AE; *Depressive
Disorder--Drug
Therapy--DT; *Dyskinesia, Drug-Induced--Etiology--ET; *Posture; Age
Factors
; Aged; Basal Ganglia Diseases--Chemically Induced--CI; Parkinson
Disease,
Symptomatic--Complications--CO
CAS Registry No.: 34841-39-9 (Bupropion)
1/L/3
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
07539209 91058209
Bupropion and delirium [letter] [see comments]
Liberzon I; Dequardo JR; Silk KR
Am J Psychiatry (UNITED STATES) Dec 1990, 147 (12) p1689-90,
ISSN
0002-953X Journal Code: 3VG
Comment in Am J Psychiatry 1991 Aug;148(8):1101-2
Languages: ENGLISH
Document type: LETTER
JOURNAL ANNOUNCEMENT: 9103
Subfile: AIM; INDEX MEDICUS
Tags: Case Report; Human; Male
Descriptors: *Antidepressive Agents--Adverse Effects--AE;
*Delirium
--Chemically Induced--CI; *Propiophenones--Adverse Effects--AE;
Aged;
Amantadine--Adverse Effects--AE; Amantadine--Therapeutic
Use--TU;
Antidepressive Agents--Therapeutic Use--TU; Depressive Disorder
--Drug
Therapy--DT; Drug Therapy, Combination; Parkinson Disease--Drug
Therapy--DT
; Propiophenones--Therapeutic Use--TU
CAS Registry No.: 0 (Antidepressive Agents); 0
(Propiophenones);
34841-39-9 (Bupropion); 768-94-5 (Amantadine)
1/L/4
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
06806683 89108683
Diagnosis and treatment of depression in the elderly.
Kim KY; Hershey LA
Department of Psychiatry, State University of New York, Buffalo.
Int J Psychiatry Med (UNITED STATES) 1988, 18 (3) p211-21,
ISSN
0091-2174 Journal Code: GSJ
Languages: ENGLISH
Document type: JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
JOURNAL ANNOUNCEMENT: 8905
Subfile: INDEX MEDICUS
Depression and suicide are significant problems in the elderly, both
in
terms of their severity and their prevalence. It is particularly
difficult
to distinguish depression from early dementia, since elderly
depressed
patients often deny mood disorder and focus on their memory problems.
This
differential diagnostic dilemma is further complicated by the fact that
20
percent of Alzheimer-type dementia patients have moderate to
severe
depression. An even higher prevalence of depression can be seen in
elderly
patients with stroke or Parkinson's disease. Most all of the
depressive
disorders of the elderly are amenable to one form or combination
of
therapies: pharmacologic, electro-convulsive, or psychotherapy.
Tricyclic
antidepressants are often associated with adverse drug reactions in
the
elderly, so alternatives such as MAO inhibitors, alprazolam, bupropion
and
psychostimulants are currently being explored in this patient
population.
(56 Refs.)
Tags: Human
Descriptors: *Aged; *Depressive Disorder--Diagnosis--DI;
Antidepressive
Agents, Tricyclic--Adverse Effects--AE; Cerebrovascular
Disorders
--Complications--CO; Dementia--Diagnosis--DI; Depressive
Disorder--Therapy
--TH; Parkinson Disease--Complications--CO
CAS Registry No.: 0 (Antidepressive Agents, Tricyclic)
1/L/5
DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
05774832 86075832
Stress-induced neurological impairments in an animal model
of
parkinsonism.
Snyder AM; Stricker EM; Zigmond MJ
Ann Neurol (UNITED STATES) Nov 1985, 18 (5) p544-51, ISSN
0364-5134
Journal Code: 6AE
Contract/Grant No.: MH-00058; MH-00338; MH-20620; +
Languages: ENGLISH
Document type: JOURNAL ARTICLE
JOURNAL ANNOUNCEMENT: 8603
Subfile: INDEX MEDICUS
Adult rats were given the neurotoxin 6-hydroxydopamine (6-HDA) by
means
of cerebrospinal fluid to produce large dopamine-depleting brain
lesions.
Although the animals behaved normally in their home cages, they
became
akinetic after such treatments as glucoprivation, tail shock, and
exposure
to severe cold. The neurological impairments were related both to
the
extent of dopamine depletion and to the intensity of the stress.
Drugs
known to enhance dopaminergic function were found to reverse
the
stress-induced neurological deficits, while dopaminergic
antagonists
potentiated the debilitating effects of stress. After focal lesions
were
produced by injecting 6-hydroxydopamine directly into specific
brain
regions, stress-induced akinesia was found to correlate best with
dopamine
depletion in the corpus striatum, especially the lateral portion of
that
structure. These and other findings suggest that the acute emergence
of
parkinsonian symptoms during stress may reflect extensive damage to
the
dopaminergic nigrostriatal pathway that had been concealed in a
preclinical
phase, owing to compensatory neurochemical changes in the
dopaminergic
neurons that yet remain intact.
Tags: Animal; Male; Support, U.S. Gov't, P.H.S.
Descriptors: *Dopamine--Metabolism--ME;
*Hydroxydopamines--Pharmacology
--PD; *Parkinson Disease, Symptomatic--Chemically Induced--CI;
*Stress
--Complications--CO; Corpus Striatum--Drug Effects--DE;
Deoxyglucose
--Pharmacology--PD; Desipramine--Pharmacology--PD; Dose-Response
Relationsh
ip, Drug; Injections, Intraventricular; Neural Pathways--Drug
Effects--DE;
Norepinephrine--Metabolism--ME; Pargyline--Pharmacology--PD;
Propiophenones
--Pharmacology--PD; Rats; Rats, Inbred Strains; Receptors,
Dopamine--Drug
Effects--DE
CAS Registry No.: 0 (Hydroxydopamines); 0 (Propiophenones);
0
(Receptors, Dopamine); 1199-18-4 (Oxidopamine); 154-17-6
(Deoxyglucose)
; 34841-39-9 (Bupropion); 50-47-5 (Desipramine);
51-41-2
(Norepinephrine); 51-61-6 (Dopamine); 555-57-7 (Pargyline)
