If estrogen therapy is the culprit re: worsening symptoms but menopausal symptoms are a real problem, you might like to give herbs a try. They work differently than estrogen. I use herbs successfully but don't happen to have PD, so I can't say whether this would work. See Susun Weed's book, Wise Women's Ways for the Menopausal Years, for advice on taking herbs for menopausal symptoms.