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If estrogen therapy is the culprit re: worsening symptoms but
menopausal symptoms are a real problem, you might like to give herbs a
try.  They work differently than estrogen.  I use herbs successfully
but don't happen to have PD, so I can't say whether this would work.
See Susun Weed's book, Wise Women's Ways for the Menopausal Years, for
advice on taking herbs for menopausal symptoms.