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Cheryl and Michael, There may have been more on this subject on the list but I found this recent posting about the effect of estrogen; it may be that the estrogen your mother is taking is having a negative effect. I don't know any more than what it says here though - in my case it is my father who has PD so the question of estrogen isn't so relevant. You'll find this list a great source of support as well as information - I hope you manage to find some information to help your mother and to relieve your worries. Katie Moore International Union of Crystallography, Chester, England [log in to unmask] - ---------------------------------------------------------------------------- - -- [ From: Donna Kipp * EMC.Ver #2.10P ] -- Sessio DR: Pearlstone MM, Jewelewicz R; Kelly A C Estrogens and Parkinson's disease Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York 10032 Med Hypotheses 1994 Apr,42(4):280-2 Unique Identifier: SDILINE 94352251 There is substantial evidence that estrogens modulate the activity of dopamine in the extrapyramidal system. However there is conflicting data as to the exact mechanism of estrogen's effect. The majority of clinicians reports support an antidopaminergic effect of estrogens on Parkinson's symptoms. Generally, Parkinsonism worsens with estrogen therapy. We report a case of improvement in Parkinsonian symptoms in a premenopausal patient when put in leuprolide acetate. The pharmacologic menopause induced by leuprolide acetate leads to a hypoestrogenic state. We hypothesize that the decrease in estrogen improves Parkinson's disease symptoms via relief of its antidopaminergic effects on the nigrostriatal pathway. The address for the newsletter is: The Young Parkinson's Information and Referral Center 1042 Foxenwoods Dr, Santa Maria CA 93455 - -----------------------------------------------------------------------------