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On January 17, Ann M Strozewski <[log in to unmask]> wrote describing symptoms which are suspected to be perhaps not parkinson's because of 1- lack of apparent response to sinimet 2- a very rapid progression after not progressing much for 1.5 yrs. This sounds very much like my father. After not progressing much for several years, the symptoms increased dramatically. Also there is not an obvious effect of sinemet. The rapid progression of symptoms may have been precititated by a fall (bumped his head). He went from walking (preferably with a walker) to bed ridden, in a couple of days. He spent a week in the hospital, and then had to go to a nursing home. He is now in a wheelchair. He also has severe dementia. His neurologist, who we think is quite good, does not feel this is unusual. His comment is that after any period of immobility, such as the time he spent in the hospital, it is extremely difficult to work back to where he was. His feeling is that even if he put forth supreme effort to get back some mobility, he would soon end up back in the wheelchair. Besides, in his current mental state he does not seem capable of embarking on a rehabilitation program and sticking with it, noting progress, etc. The neurologist sees nothing unusual and does not suspect any other diagnosis. In summary, he seems characterized by: -little apparent response to sinemet -severe dementia -hallucinations -no longer can walk -unclear speech -mild tremor -very rapid progression in a short time He is taking 3X sinemet CR. He was taking 2X eldepryl, but we discontinued based on comments from this list saying the eldepryl was bad for mental confusion. But discontinuing eldepryl apparently had no positive effect. Any comments? Thanks... Warren Whitney Ann Arbor, MI email [log in to unmask] or [log in to unmask]