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Hi Edward. Glad you came out of lurk-land to ask your questions. Those of us who care for PD parents/loved ones, know that ups and downs are part and parcel of the condition. All the things you listed as problems are indications that your mother needs lots of moral support and contact with people, as well as exercise, good diet and perhaps a new evaluation of her physical condition from another MD. Changes are hard, but some are worth the effort. At the risk of sounding like a broken record, please have her doctor order some home-health-care nurses, therapists, whatever he deems proper for her. They are a God-send, and will help tremendously also in the area of human contact. They are a caring and dedicated group of people. I don't know anything about your area, but feel certain these resources are available to you there. Best wishes to you and your Mom as you explore her options, and know that there are many of us out here who have and are in your shoes. Lynn Lowe