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Dave: It is as likely that the Amitryptiline was responsible for the changes as was the generic Sinemet. Most generic drugs are fine, there are a few exceptions, and I was not aware that Sinemet was one of them. Best, Bob -- ******************************************************** Robert A. Fink, M. D., F.A.C.S. Phone: 510-849-2555 Neurological Surgery FAX: 510-849-2557 2500 Milvia Street Suite 222 Berkeley, California 94704-2636 USA E-Mail: [log in to unmask] CompuServe: 72303,3442 America Online: BobFink "Ex Tristitia Virtus" ********************************************************