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Someone posted a message to me last night or today concerning the possible relationship between PD and head injury. I, unfortunately, did not save the message and said that I had previously posted such a search result. I was mistaken; I had posted a head injury search connected with another disorder on another List. Below is the result of a MEDLINE search done today on this subject. I only found 3 articles (1985-present) and there is only small association present in these. For what it is worth; here it is: --------------------------------------------------------------------- 1/L/4 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 07973041 92111041 [A case of posttraumatic parkinsonism] Takeda M; Okuda B; Tomino Y; Tachibana H; Sugita M Fifth Department of Internal Medicine, Hyogo College of Medicine. Rinsho Shinkeigaku (JAPAN) Aug 1991, 31 (8) p842-6, ISSN 0009-918X Journal Code: DF2 Languages: JAPANESE Summary Languages: ENGLISH Document type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES English Abstract JOURNAL ANNOUNCEMENT: 9204 Subfile: INDEX MEDICUS We report a case of a 52-year-old man with posttraumatic parkinsonism. He was admitted to our department because of right-sided hand tremor and gait disturbance. He had suffered from a severe head injury incurred in a traffic accident with brief unconsciousness 6 months before admission. Three weeks after his injury, tremor and rigidity in the right upper limb developed, and he walked dragging his right leg. Five months after his injury, he received 1-dopa therapy, exhibiting a moderate improvement in parkinsonian symptoms. On admission, he was demented to a mild degree with masked face and monotonous speech. He presented with resting-postural-kinetic tremor and muscle rigidity on the right side. Cranial CT and MRI showed no abnormality. Inter-peak latencies of waves III to V of BAEP were significantly longer in this patient than in normal subjects. This BAEP findings suggested an upper brainstem lesion. 123I-IMP SPECT disclosed decreased cerebral blood flow in the left thalamus, bilateral frontal and parietal cortices. We diagnosed this case as having posttraumatic parkinsonism. Parkinsonism in the present case may be due to the involvement of multiple neuronal circuits of the extrapyramidal system at the level of the midbrain to the thalamus. (15 Refs.) Tags: Case Report; Human; Male Descriptors: *Head Injuries--Complications--CO; *Parkinson Disease, Symptomatic--Etiology--ET; Amphetamines--Diagnostic Use--DU; Iodine Radioisotopes--Diagnostic Use--DU; Middle Age; Parkinson Disease, Symptomatic--Radionuclide Imaging--RI; Tomography, Emission-Computed, Single-Photon CAS Registry No.: 0 (Amphetamines); 0 (Iodine Radioisotopes); 95896-48-3 (iofetamine) 1/L/5 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 07879936 92017936 Prior history of head trauma in Parkinson's disease. Factor SA; Weiner WJ Department of Neurology, Albany Medical College, NY 12208. Mov Disord (UNITED STATES) 1991, 6 (3) p225-9, ISSN 0855-3185 Journal Code: NIA Languages: ENGLISH Document type: JOURNAL ARTICLE JOURNAL ANNOUNCEMENT: 9201 Subfile: INDEX MEDICUS The purpose of this study was to evaluate the relationship between head trauma and Parkinson's disease (PD). A questionnaire was completed by 97 PD patients (mean age 68.6 years, duration of disease 6.4 years) and 64 spouses acting as controls (mean age 63 years). Thirty-one PD patients reported head trauma before onset of PD (mean 32.3 years earlier), whereas 11 controls reported head injury before completing the survey (mean 26 years earlier) (p less than 0.05). Twenty PD patients and five controls reported head injury associated with alteration or loss of consciousness (p less than 0.05). Injury occurred a mean of 37.7 years before onset of PD and 37.2 years before survey completion in the two groups, respectively. In both of these comparisons we adjusted the frequencies to eliminate sex differences between groups. Comparison of new frequencies showed differences that were not significant. However, a trend toward significance was observed when examining head trauma with alteration of consciousness. Other investigators have reported similar results indicating that previous head trauma may be a risk factor in the etiology of PD. However, recall bias might have an effect on the outcome of these studies and this is discussed. The relationship between head trauma and PD is still tenuous. Tags: Comparative Study; Female; Human; Male; Support, Non-U.S. Gov't Descriptors: *Head Injuries--Complications--CO; *Parkinson Disease --Etiology--ET; Adult; Aged; Bias (Epidemiology); Consciousness; Middle Age ; Questionnaires; Retrospective Studies; Risk Factors 1/L/8 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 05657021 85273021 Posttraumatic parkinsonism. Nayernouri T Surg Neurol (UNITED STATES) Sep 1985, 24 (3) p263-4, ISSN 0090-3019 Journal Code: VBJ Languages: ENGLISH Document type: JOURNAL ARTICLE JOURNAL ANNOUNCEMENT: 8511 Subfile: INDEX MEDICUS Development of parkinsonian features following a blunt head injury in a 37-year-old man is described. High definition computed tomography scan of the midbrain demonstrated low-density lesions in the region of substantia nigra. Tags: Case Report; Human; Male Descriptors: *Brain Injuries--Complications--CO; *Parkinson Disease --Etiology--ET; Adult; Head Injuries--Complications--CO