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Dear Barbara: My husband has long had this symptom, several years before he began taking Sinemet CR, as a matter of fact. Now that his Sinemet is being reduced and Permax increased, he suffers it less frequently. He takes both Sinemet CR (1.5 5/250 pills daily) and regular Sinemet (1 25/100, split in two and taken at two different times. But the RLS has been there for at least eight years or more, and seems to be a symptom of overdose. Perhaps your observation linking Sinemet CR with RLS has more to do with some portion of the day when tissues are saturated with medication rather than the controlled release aspect. I also think it's related to the on-off syndrome, but these matters are so subtle that they defy any true categorization, at least for us. k. --------------------------------------------------------------------------- Mrs. Karin M. Beros, MSO [log in to unmask] International and Area Studies voice: (510) 642-8542 Office of the Dean, 260 Stephens Hall fax: (510) 642-9466 --------------------------------------------------------------------------- On Sun, 19 Feb 1995 [log in to unmask] wrote: > All: Have you noticed something interesting - namely that RLS was never > mentioned at Parkinson's seminars, regional meetings, in medical journals, > PD newsletters, or support groups until recently? And note that Controlled > Release Sinemet came on the market 3-4 years ago? > > Since my first message re restless leg syndrome, I have received E-mail > from several people with PD who have restless legs. Some said they felt > Sinemet CR was a problem. One said her neurologist took her off CR and put > on regular Sinemet and her muscle spasms improved. > > RLS can cause insomnia. Many people spend their evenings and nights pacing > the floor or exercising to relieve the need to move their legs. Relief is > short lived and the twitching, crawling, pulling, shocking, drawing and > tingling sensations often re-occur when they sit or lie down to rest. These > sensations sometimes plague the sufferer when traveling which can turn a nice > trip into a nightmare. > > Does anyone have a problem with Sinemet CR in this regard? > > Barbara Yacos > <[log in to unmask]> >