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Part Two of MEDLINE on PD and childhood diseases, influenza, and environmental exposures. ------------------------------------------------------------------- 3/L/25 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 07524547 91043547 Hemiparkinsonism-hemiatrophy syndrome: clinical and neuroradiologic features. Giladi N; Burke RE; Kostic V; Przedborski S; Gordon M; Hunt A; Fahn S Neurological Institute, College of Physicians and Surgeons of Columbia University, New York, NY. Neurology (UNITED STATES) Nov 1990, 40 (11) p1731-4, ISSN 0028-3878 Journal Code: NZ0 Contract/Grant No.: R-29 NS26836, NS, NINDS Languages: ENGLISH Document type: JOURNAL ARTICLE JOURNAL ANNOUNCEMENT: 9102 Subfile: AIM; INDEX MEDICUS We evaluated 11 patients with hemiparkinson-hemiatrophy syndrome, 6 with body and contralateral cerebral hemispheric hemiatrophy, 4 with only body hemiatrophy, and 1 with just brain hemiatrophy. The mean age of symptom onset was 38.1 years (range, 18 to 54) with 5.2 +/- 3.1 (mean +/- SD) years of illness until the last follow-up visit. The presenting symptom was unilateral tremor in 6 patients, hand dystonia in 2, bradykinesia in 2, and abnormal gait in 1 patient. Three patients had a good response to levodopa, 4 had moderate response, and 2 patients had a poor response. During a mean follow-up period of 1.7 years (range, 4 months to 5 years), the Hoehn and Yahr score changed in only 3 patients: 2 gained 1.5 points and 1 gained 3 points over 2.5 years. We discuss the association between hemiparkinsonism-body hemiatrophy and contralateral hemispheric hemiatrophy, and raise the possibility of early childhood brain insult with delayed-onset parkinsonism. Tags: Female; Human; Male; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S. Descriptors: *Brain--Pathology--PA; *Extremities--Pathology--PA; *Parkinson Disease, Symptomatic--Diagnosis--DI; Adolescence; Adult; Atrophy ; Brain--Radiography--RA; Follow-Up Studies; Levodopa--Therapeutic Use--TU; Magnetic Resonance Imaging; Middle Age; Parkinson Disease, Symptomatic --Drug Therapy--DT; Parkinson Disease, Symptomatic--Radiography--RA; Retrospective Studies; Syndrome; Tomography, X-Ray Computed CAS Registry No.: 0 (Levodopa) 3/L/33 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 06407280 88052280 Environmental factors in the etiology of Parkinson's disease. Tanner CM; Chen B; Wang WZ; Peng ML; Liu ZL; Liang XL; Kao LC; Gilley DW; Schoenberg BS Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL. Can J Neurol Sci (CANADA) Aug 1987, 14 (3 Suppl) p419-23, ISSN 0317-1671 Journal Code: CJ9 Languages: ENGLISH Document type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL JOURNAL ANNOUNCEMENT: 8803 Subfile: INDEX MEDICUS Parkinson's disease (PD) has been proposed to result from the interaction of aging and environment in susceptible individuals. Defective metabolism of debrisoquine, inherited as an autosomal recessive, has been associated with this susceptibility. In 35 PD patients and 19 age-matched controls, no significant differences in debrisoquine metabolism were found, although a trend to impaired metabolism was noted in patients with disease onset less than or equal to 40. Foci of PD patients were associated with rural living and well water drinking, or rural living coupled with market gardening or wood pulp mills. In a questionnaire survey, patients with PD onset less than or equal to age 47 were significantly more likely to have lived in rural areas and to have drunk well water than those with onset greater than or equal to age 54 (p less than or equal to 0.01). Because of population mobility in North America, a case-control study designed to test environmental, occupational, dietary and other proposed risk factors for PD was conducted in China, where the population is more stationary and the environment more stable. No significant differences in incidences of head trauma, smoking or childhood measles were found between patients and controls. (47 Refs.) Tags: Female; Human; Male; Support, Non-U.S. Gov't Descriptors: *Environment; *Parkinson Disease, Symptomatic--Etiology--ET ; Adult; Environmental Pollution--Adverse Effects--AE; Middle Age; Parkinson Disease, Symptomatic--Chemically Induced--CI; Parkinson Disease, Symptomatic--Genetics--GE; Rural Population; Smoking--Adverse Effects--AE; Stress--Complications--CO 3/L/34 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 06407279 88052279 Geography, drinking water chemistry, pesticides and herbicides and the etiology of Parkinson's disease. Rajput AH; Uitti RJ; Stern W; Laverty W; O'Donnell K; O'Donnell D; Yuen WK; Dua A Department of Clinical Neurological Sciences, University Hospital, Saskatoon, Saskatchewan, Canada. Can J Neurol Sci (CANADA) Aug 1987, 14 (3 Suppl) p414-8, ISSN 0317-1671 Journal Code: CJ9 Languages: ENGLISH Document type: JOURNAL ARTICLE JOURNAL ANNOUNCEMENT: 8803 Subfile: INDEX MEDICUS In 1984 we made the first observation of a correlation between early age exposure to rural environment (and drinking well water) and development of idiopathic Parkinson's disease (IPD). These findings were subsequently confirmed elsewhere (Barbeau, 1985;25 Tanner, 1985). Analysis of all early age onset IPD (EPD) cases born and raised in Saskatchewan revealed that 20 of 22 had exclusively rural exposure during the first 15 years of life. This distribution was significantly different from the general population (p = 0.0141). Further study of the EPD group included sampling and metal analysis of childhood sources of drinking water in 18 cases and 36 age and sex-matched controls. Water collected from the two groups was analyzed for 23 metals (including 7 elements implicated in the etiology of IPD). There was no difference in the metal composition of the water between the two groups. Finally, a review of herbicide and pesticide use in Saskatchewan agriculture was undertaken to determine if there was an increased incidence of EPD following utilization of any particular chemical. No increase was found in the incidence of EPD with the introduction of any pesticide or herbicide, including Paraquat, for agricultural use. We conclude that there is a strong correlation between early age rural environmental exposure and development of IPD. We believe well water is a likely vehicle for the causal agent, but neither water metal concentration nor any of the herbicides and pesticides used in Saskatchewan agriculture are related to the cause. Tags: Human Descriptors: *Environmental Pollution--Adverse Effects--AE; *Herbicides --Adverse Effects--AE; *Parkinson Disease, Symptomatic--Chemically Induced --CI; *Pesticides--Adverse Effects--AE; *Water Pollution, Chemical--Adverse Effects--AE; Adult; Canada; Middle Age; Parkinson Disease, Symptomatic --Epidemiology--EP; Parkinson Disease, Symptomatic--Etiology--ET CAS Registry No.: 0 (Herbicides); 0 (Pesticides) 3/L/35 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 06178651 87152651 Early onset Parkinson's disease and childhood environment. Rajput AH; Uitti RJ; Stern W; Laverty W Adv Neurol (UNITED STATES) 1987, 45 p295-7, ISSN 0091-3952 Journal Code: 2NX Languages: ENGLISH Document type: JOURNAL ARTICLE JOURNAL ANNOUNCEMENT: 8706 Subfile: INDEX MEDICUS Tags: Human; Support, Non-U.S. Gov't Descriptors: *Parkinson Disease--Etiology--ET; *Social Environment; Adult ; Aged; Follow-Up Studies; Middle Age; Risk; Rural Population; Saskatchewan ; Urban Population 3/L/36 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 06077110 87051110 Early onset Parkinson's disease in Saskatchewan--environmental considerations for etiology. Rajput AH; Uitti RJ; Stern W; Laverty W Can J Neurol Sci (CANADA) Nov 1986, 13 (4) p312-6, ISSN 0317-1671 Journal Code: CJ9 Languages: ENGLISH Document type: JOURNAL ARTICLE JOURNAL ANNOUNCEMENT: 8703 Subfile: INDEX MEDICUS The cause of idiopathic Parkinson's Disease (PD) is not known but it is believed to be related to some environmental agent(s). Given a long preclinical interval and onset of symptomatology around age 60 years, it becomes impossible to identify and analyze all prior environmental factors satisfactorily. To circumvent these difficulties we evaluated the childhood environment in those PD patients whose symptoms began at age 40 years or earlier. Twenty-one such cases were born and raised in the province of Saskatchewan. Nineteen of these 21 patients spent the first 15 years of life exclusively in rural Saskatchewan. Detailed population analysis indicates a strong predisposition to early onset idiopathic Parkinson's Disease (EPD) in those raised in rural areas (p = 0.0154). All but one case utilized exclusively well water for the first 15 years of life--a trait significantly different from that expected in the provincial population. It is concluded that rural Saskatchewan environments contribute to EPD and that well water used in childhood should be considered as a potential vehicle for the etiological agent. Tags: Human; Support, Non-U.S. Gov't Descriptors: *Parkinson Disease--Etiology--ET; *Water Supply; Age Factors ; Environment; Parkinson Disease--Epidemiology--EP; Retrospective Studies; Rural Population; Saskatchewan; Urban Population 3/L/39 DIALOG(R)File 154:MEDLINE(R) (c) format only 1995 Knight-Ridder Info. All rts. reserv. 05746779 86047779 Measles infection and Parkinson's disease. Sasco AJ; Paffenbarger RS Jr Am J Epidemiol (UNITED STATES) Dec 1985, 122 (6) p1017-31, ISSN 0002-9262 Journal Code: 3H3 Contract/Grant No.: CA 25264 Languages: ENGLISH Document type: JOURNAL ARTICLE JOURNAL ANNOUNCEMENT: 8602 Subfile: INDEX MEDICUS A case-control analysis of Parkinson's disease and infections in childhood was conducted in a cohort of 50,002 men who attended Harvard College (Cambridge, MA) or the University of Pennsylvania (Philadelphia, PA) between 1916 and 1950 and who were followed in adulthood for morbidity and mortality data. Cases of Parkinson's disease were identified from responses to mailed questionnaires and death certificates through 1978. Four controls from the same population were selected for each case. A reduced risk of Parkinson's disease was associated with most childhood viral infections. The negative association was statistically significant for a history of measles prior to college entrance (exposure odds ratio = 0.53; 95% confidence limits: 0.31, 0.93). The reduced risk of Parkinson's disease among subjects with a positive history of measles in childhood may reflect an adverse effect of measles in adulthood or of subclinical or atypical measles. Furthermore, a negative history of measles, especially if associated with a lack of other common diseases, could be a marker for negative influenza history before 1918 and thus a higher risk of infection during the 1918 influenza epidemic, because of the lack of partial influenza immunity. These data may also suggest a truly protective effect of measles, compatible with some complex interaction between measles virus and the virus of the 1918 influenza epidemic. Tags: Human; Male; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S. Descriptors: *Measles--Complications--CO; *Parkinson Disease--Etiology --ET; Adolescence; Adult; Aged; Child; Child, Preschool; Death Certificates ; Epidemiologic Methods; Infant; Influenza--Complications--CO; Longitudinal Studies; Massachusetts; Measles--Epidemiology--EP; Middle Age; Parkinson Disease--Epidemiology--EP; Parkinson Disease--Mortality--MO; Pennsylvania; Questionnaires; Regression Analysis; Risk _====================================================================== Hopes this is helpful. Best, Bob -- ******************************************************** Robert A. Fink, M. D., F.A.C.S. Phone: 510-849-2555 Neurological Surgery FAX: 510-849-2557 2500 Milvia Street Suite 222 Berkeley, California 94704-2636 USA E-Mail: [log in to unmask] CompuServe: 72303,3442 America Online: BobFink "Ex Tristitia Virtus" ********************************************************