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Bruce McCallum womders if taking Sinemet speeds up the destruction of dopamine producing cells in the brain. From all that I have read or heard at scientific meetings, there does not appear to be any sound evidence to support the concept that sinemet has that sort of deleterious effect. It is true that some individuals delay taking levodopa (Sinemet) until their Parkinson's disease has grossly interfered with their lives. I think they are making life difficult for themselves by choosing this coure of disease management. Parkinson's is a