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Antioxidant vitamins C and E (free-radical scavengers) and Eldepryl were both found to have negligble effect as measured by analysis of spinal fluid for the products of dopamine metabolism (including <free radicals>. Elderpryl appeared to postpone the need for symptomatic treatment because it itself provided some symptomatic relief. This makes sense because it does block the metabolism of dopamine to some limited degree and thus, theoretically, makes more dopamine available in the synapse. This is my translation of what I have been told by Dr. Stanley Fahn of Columbia Presbyterian in NYC who directed the Datatop study. Fahn's perscription for me, a newly diagnosed (first anniversary upcoming) young onset PD (age 42): take 3000 mgs of Vitamins E and C (it can't hurt) and 30 mg daily of Parnate, a MAO A AND MAO B inhibitor. Again, theoretically better at blocking the metabolism of dopamine than Eldepryl which inhibits only MAO B. Others think Eldepryl works by a means undetected by the Datatop study, I have read. Best regards, David