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This is my first message to the list. I've been lurking since the middle of January. I joined to be able to share your letters with my mother. She is 82 and has been diagnosed with PD for about 7 to 8 years, though she now recognizes that she had symptoms before that. She is on Sinemet, the pink pill, at about 4 1/2 hour intervals. She must take the quick acting yellow pill (Sinemet) when she first awakens in the morning. If she goes past the 4 1/2 mark, she quickly loses the movement she does have. She now walks with much difficulty with the lighest walker, has occasional falls. Her speech is much affected, though her mind is as active as ever. She is greatly interested in your letters and asked me to ask the list, "What is after Sinemet?" She has RLS and has great difficulty at night because she cannot easily get up from her bed, can often fall off the edge to the floor, on be found in the morning hanging on because she couldn't make it completely off. Needless to say, she has difficulty exercising the RLS away in the middle of the night. Can anyone tell her of further medication if and when the Sinemet is no longer effective, or only for short periods?