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I'm writing for my mother who has been diagnosed with PD for about seven years, but most certainly had symptoms before that. She is 82, has lost some strength lately so that walking with the lightweight walker is slow business. She has falls, difficulty getting in and out of bed, RLS, speech is affected, eyesight, too (doctors say eyes don't work together anymore, therefore double vision). Takes Sinemet every 4.5 to 5 hours. She can tell when she has missed her medication time, ability to move around is quickly affected. Takes a yellow quick-acting Sinemet at 6:30am to be able to get going, then 1 and one-half pink Sinement before getting out of bed. The rest of the day it's one pink Sinemet at her regular dosage times. She is very concerned about what can come next if the Sinement should quit being effective. Has anyone had experience with Sinement becoming ineffective? If so, what's next?