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I think it would be useful to put out on the net the list of possible side-effects of Sinamet, just so we can all be aware of how PD and Sinamet might interact. As usual, this list cites ALL recorded side-effects, not to imply that all, some, or any might affect any one individual. My aunt sent me this, copied from "The Pill Book." It was helpful for my mother to see this list, because it made her feel better about the trouble she has been having with memory, hallucinations, etc. Note: the side-effects of any drug are always startling in their number and scariness; this list should not prompt people to seek immediately to go off Sinamet, which also has vital good effects. Possible side effects: Uncontrolled muscle movements [!!], loss of appetite, nausea, vomiting, stomach pain, dry mouth, difficulty swallowing, dribbling saliva from the side of the mouth, shaking of the hands, headache, dizziness, numbness, weakness, feeling faint, grinding of the teeth, confusion, sleeplessness, nightmares, hallucinations, anxiety, agitation, tiredness, feeling of ill health, feeling of euphoria. Less Common Side-effects: Heart palpitations, dizziness when rising quickly from a sitting position, sudden extreme slowness of movement (on-off phenomenon), mental changes, including paranoia, psychosis and depression, and slowdown of mental functioning. Other side-effects include difficult urination, muscle twitching, spasms of the eyelids, lockjaw, burning sensation on the tongue, bitter taste, diarrhea, constipation, stomach gas, flushing of the skin, rash, sweating, unusual breathing, double or blurred vision, dilation of the pupils of the eyes, hot flashes, changes in body weight, darkening of the urine or sweat. Occasionally Sinamet may cause bleeding of the stomach or development of an ulcer, high blood pressure, adverse effects on components of the blood, irritation of blood vessels, hiccups, feeling of being stimulated, retention of body fluid, hair loss, hoarseness of the voice, or persistent penile erection. _______ P.S. Many thanks for Dr. Kelly's WONDERFUL rebuttal to that sensationalist NYT article. Virginia Tilley [log in to unmask]