A friend has been taking Sinemet for over 20 years, and they are no longer having the effect they originally did. Of an evening, 1 tablet sends him to sleep for four hours (1/2 a tab for 2!), then his wakes, is fine for half an hour, stiffens, takes another tablet and goes back to sleep. Expensive sleeping pill! Any helpful suggestions to alieve this pattern? David Maegraith [log in to unmask]