Hi , just a note to introduce myself. I'm 50, Dx'ed in 1989, on Long-term disability since March 1993.. was a mgr of financial analysts. Am comfortably living in Lombard, Ill. Meds are 3 50/200 SinemetCR , 2 Permax .25mg... supplemented with 10-100 Sinemet as required. My neuro is not keen on eldepryl.. My major lament is sleep difficulty, although the PD itself effects primarily my movement.. ( frequently I can't roll over in bed, or during the day I will just be unable to move my arms. If over-dosed or watching a stressful scene on TV my hands clutch and unclutch.. Exercise includes hand weights and stretching/mobility. I follow Prodigy ,Will Johnston's fine newsletter, and the research pubs of the United Parkinson's Foundation. New agonists and surgical methods seem tooffer temporary symptomatic relief , but I suspect genetic wizardary is going to offer the ultimate solution. Nice to be a part of you , I hope to learn and contribute. John Mier