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I joined the network several weeks ago and have been amazed at the free exchange of ideas and amount of PD information I have gained from so many different subscribers. I was diagnosed PD one year ago based on Carbi-L-Dopa immediatley relieving my 6-S's: slow, stiff, sore, stooped and short stride. I am currently doing OK on 5 mg Eldepryl & 1 25/100 Sinemet daily with tremor being my main but bearable symptom. I retired 5 years ago. P.E. instructor @ Southeast Mo. Univ. Cape Girardeau. Questions: Could there be a connection between liver damage and/or folic acid deficiency and the onset of my PD? Could there be some unknown enzyme, chemical, bacteria, critter or whatever lurking in the liver that has something to do with the metabolism of dopamine or it's percursors before it reaches the brain? I pose this question because I suffered liver damage(temporary, I hope) from taking the drug NIZORAL (ketoconazole) for a yeast infection and about a month later the first vague symptoms started with teeny foot tremors and muscle fasicullations in the calves of both legs. 8 months later symptoms had worsened and tests were done. The only positive test showed a very low folate level which was quickly reversed with folic acid tablets (B-12 level was OK.) Diagnosis at that time was RLS. Symptoms continued to worsen to my forementioned 6-S's; a total 3 years before the neurologist agreed with me that I had PD. Margaret Mates C311edh@SEMOVM